Calcium in PDB 7sim: Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor

The binding sites of Calcium atom in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor (pdb code 7sim). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor, PDB code: 7sim:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca904 b:37.5 occ:1.00 O A:LEU88 2.5 34.9 1.0 O A:LEU87 2.5 32.7 1.0 O A:ILE81 2.9 24.2 1.0 O A:SER84 3.1 33.8 1.0 C A:LEU88 3.2 34.9 1.0 O A:LEU91 3.6 37.5 1.0 C A:LEU87 3.7 32.7 1.0 O A:ASN82 3.7 27.4 1.0 N A:PRO89 4.0 37.1 1.0 CB A:LEU88 4.0 34.9 1.0 C A:ILE81 4.0 24.2 1.0 CA A:LEU88 4.0 34.9 1.0 CA A:ASN82 4.1 27.4 1.0 CA A:PRO89 4.1 37.1 1.0 C A:ASN82 4.2 27.4 1.0 N A:LEU88 4.3 34.9 1.0 C A:SER84 4.3 33.8 1.0 N A:ASN82 4.5 27.4 1.0 C A:PRO89 4.7 37.1 1.0 CA A:PRO85 4.8 36.4 1.0 N A:ASN90 4.8 38.7 1.0 C A:LEU91 4.8 37.5 1.0 CG2 A:ILE81 4.8 24.2 1.0 CA A:LEU87 4.9 32.7 1.0 N A:LEU91 4.9 37.5 1.0 OG A:SER84 5.0 33.8 1.0

Calcium binding site 2 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca905 b:39.1 occ:1.00 OG1 A:THR100 2.7 22.0 1.0 N A:THR145 3.3 19.6 1.0 CB A:THR145 3.4 19.6 1.0 OG1 A:THR145 3.6 19.6 1.0 CB A:ALA144 3.7 17.9 1.0 CB A:THR100 3.8 22.0 1.0 CA A:THR145 3.8 19.6 1.0 N A:GLY146 4.0 20.8 1.0 OD1 A:ASN102 4.0 23.3 1.0 CG2 A:THR100 4.0 22.0 1.0 CB A:PRO39 4.1 19.9 1.0 CD A:PRO39 4.2 19.9 1.0 N A:PRO39 4.2 19.9 1.0 CG A:PRO39 4.2 19.9 1.0 CG1 A:VAL149 4.3 21.3 1.0 C A:ALA144 4.3 17.9 1.0 CA A:ASN102 4.4 23.3 1.0 CA A:ALA144 4.4 17.9 1.0 C A:THR145 4.4 19.6 1.0 N A:ASN102 4.5 23.3 1.0 C A:PHE38 4.5 17.5 1.0 CA A:PRO39 4.5 19.9 1.0 CB A:VAL149 4.7 21.3 1.0 CG2 A:THR145 4.7 19.6 1.0 CG A:ASN102 4.8 23.3 1.0 OH A:TYR167 4.8 17.2 1.0 CG2 A:VAL149 4.9 21.3 1.0 CA A:PHE38 4.9 17.5 1.0 O A:PHE38 4.9 17.5 1.0

Calcium binding site 3 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca906 b:35.9 occ:1.00 OG A:SER302 2.7 27.5 1.0 CB A:SER302 3.5 27.5 1.0 CA A:GLY273 3.9 24.7 1.0 CD A:PRO274 4.0 25.2 1.0 N A:GLY273 4.1 24.7 1.0 CE1 A:PHE42 4.1 22.6 1.0 CA A:SER302 4.1 27.5 1.0 CD1 A:LEU304 4.4 26.5 1.0 O A:ALA298 4.4 23.3 1.0 CG A:LEU304 4.5 26.5 1.0 CZ3 A:TCR902 4.5 18.8 1.0 C A:GLY273 4.7 24.7 1.0 N A:PRO274 4.7 25.2 1.0 CH2 A:TCR902 4.8 18.8 1.0 CD1 A:PHE42 4.8 22.6 1.0 N A:SER303 4.9 27.8 1.0 CG A:PRO274 4.9 25.2 1.0 CZ A:PHE42 4.9 22.6 1.0 C A:SER302 4.9 27.5 1.0 NH1 A:ARG66 5.0 21.5 1.0 CB A:LEU304 5.0 26.5 1.0

Calcium binding site 4 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca907 b:45.5 occ:1.00 O A:GLY557 2.4 44.3 1.0 C A:GLY557 3.5 44.3 1.0 OD2 B:ASP234 3.8 45.8 1.0 OD1 B:ASP234 3.9 45.8 1.0 CA A:GLY557 4.0 44.3 1.0 CG B:ASP234 4.2 45.8 1.0 O B:GLU231 4.4 44.1 1.0 N A:GLU558 4.5 46.0 1.0 CA A:GLU558 4.8 46.0 1.0

Calcium binding site 5 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca904 b:37.6 occ:1.00 O B:LEU87 2.5 32.9 1.0 O B:LEU88 2.5 35.3 1.0 O B:SER84 3.2 33.7 1.0 O B:ILE81 3.2 24.4 1.0 C B:LEU88 3.3 35.3 1.0 O B:LEU91 3.6 37.9 1.0 O B:ASN82 3.7 28.0 1.0 C B:LEU87 3.7 32.9 1.0 N B:PRO89 4.0 38.0 1.0 CB B:LEU88 4.0 35.3 1.0 CA B:LEU88 4.0 35.3 1.0 CA B:ASN82 4.1 28.0 1.0 CA B:PRO89 4.1 38.0 1.0 C B:ASN82 4.2 28.0 1.0 C B:ILE81 4.2 24.4 1.0 N B:LEU88 4.3 35.3 1.0 C B:SER84 4.4 33.7 1.0 N B:ASN82 4.6 28.0 1.0 C B:PRO89 4.7 38.0 1.0 N B:ASN90 4.8 39.8 1.0 C B:LEU91 4.8 37.9 1.0 CG2 B:ILE81 4.8 24.4 1.0 CA B:PRO85 4.9 36.5 1.0 OD1 B:ASN82 4.9 28.0 1.0 CA B:LEU87 4.9 32.9 1.0 N B:LEU91 4.9 37.9 1.0 OG B:SER84 5.0 33.7 1.0

Calcium binding site 6 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca905 b:35.3 occ:1.00 OG1 B:THR100 2.7 22.4 1.0 N B:THR145 3.3 19.6 1.0 CB B:THR145 3.4 19.6 1.0 OG1 B:THR145 3.5 19.6 1.0 CB B:ALA144 3.7 17.2 1.0 CB B:THR100 3.7 22.4 1.0 CA B:THR145 3.8 19.6 1.0 OD1 B:ASN102 3.9 22.7 1.0 N B:GLY146 4.0 21.3 1.0 CG2 B:THR100 4.0 22.4 1.0 CB B:PRO39 4.1 19.7 1.0 CG B:PRO39 4.2 19.7 1.0 CD B:PRO39 4.2 19.7 1.0 N B:PRO39 4.2 19.7 1.0 CG1 B:VAL149 4.3 21.5 1.0 C B:ALA144 4.3 17.2 1.0 CA B:ASN102 4.3 22.7 1.0 CA B:ALA144 4.4 17.2 1.0 C B:THR145 4.4 19.6 1.0 N B:ASN102 4.5 22.7 1.0 C B:PHE38 4.5 17.6 1.0 CA B:PRO39 4.6 19.7 1.0 CB B:VAL149 4.7 21.5 1.0 CG2 B:THR145 4.7 19.6 1.0 CG B:ASN102 4.8 22.7 1.0 OH B:TYR167 4.8 16.7 1.0 CG2 B:VAL149 4.9 21.5 1.0 CA B:PHE38 4.9 17.6 1.0 O B:PHE38 5.0 17.6 1.0

Calcium binding site 7 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca906 b:35.9 occ:1.00 OG B:SER302 2.7 26.8 1.0 CB B:SER302 3.5 26.8 1.0 CA B:GLY273 3.9 26.6 1.0 CD B:PRO274 4.0 26.0 1.0 N B:GLY273 4.1 26.6 1.0 CA B:SER302 4.2 26.8 1.0 CE1 B:PHE42 4.2 23.1 1.0 O B:ALA298 4.4 23.3 1.0 CG B:LEU304 4.4 27.3 1.0 CD1 B:LEU304 4.5 27.3 1.0 CZ3 B:TCR902 4.6 19.0 1.0 C B:GLY273 4.7 26.6 1.0 N B:PRO274 4.7 26.0 1.0 CH2 B:TCR902 4.8 19.0 1.0 CG B:PRO274 4.9 26.0 1.0 CD1 B:PHE42 4.9 23.1 1.0 N B:SER303 4.9 28.2 1.0 CB B:LEU304 4.9 27.3 1.0 C B:SER302 5.0 26.8 1.0 CZ B:PHE42 5.0 23.1 1.0

Calcium binding site 8 out of 8 in the Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Structure of Positive Allosteric Modulator-Free Active Human Calcium- Sensing Receptor within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca907 b:43.6 occ:1.00 O B:GLY557 2.4 44.5 1.0 C B:GLY557 3.4 44.5 1.0 OD2 A:ASP234 3.5 44.9 1.0 OD1 A:ASP234 3.6 44.9 1.0 CG A:ASP234 3.9 44.9 1.0 CA B:GLY557 4.0 44.5 1.0 O A:GLU231 4.4 44.6 1.0 N B:GLU558 4.4 46.1 1.0 CA B:GLU558 4.7 46.1 1.0

J.Park, H.Zuo, A.Frangaj, Z.Fu, L.Y.Yen, Z.Zhang, L.Mosyak, V.N.Slavkovich, J.Liu, K.M.Ray, B.Cao, F.Vallese, Y.Geng, S.Chen, R.Grassucci, V.P.Dandey, Y.Z.Tan, E.Eng, Y.Lee, B.Kloss, Z.Liu, W.A.Hendrickson, C.S.Potter, B.Carragher, J.Graziano, A.D.Conigrave, J.Frank, O.B.Clarke, Q.R.Fan. Symmetric Activation and Modulation of the Human Calcium-Sensing Receptor. Proc.Natl.Acad.Sci.Usa V. 118 2021.
ISSN: ESSN 1091-6490
PubMed: 34916296
DOI: 10.1073/PNAS.2115849118