Atomistry » Calcium » PDB 7tci-7ubr » 7uab
Atomistry »
  Calcium »
    PDB 7tci-7ubr »
      7uab »

Calcium in PDB 7uab: Human Pro-Meprin Alpha (Zymogen State)

Enzymatic activity of Human Pro-Meprin Alpha (Zymogen State)

All present enzymatic activity of Human Pro-Meprin Alpha (Zymogen State):
3.4.24.18;

Other elements in 7uab:

The structure of Human Pro-Meprin Alpha (Zymogen State) also contains other interesting chemical elements:

Zinc (Zn) 4 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Human Pro-Meprin Alpha (Zymogen State) (pdb code 7uab). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 7 binding sites of Calcium where determined in the Human Pro-Meprin Alpha (Zymogen State), PDB code: 7uab:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7;

Calcium binding site 1 out of 7 in 7uab

Go back to Calcium Binding Sites List in 7uab
Calcium binding site 1 out of 7 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca703

b:90.9
occ:1.00
 O A:THR287 2.3 81.9 1.0
OD1 A:ASP288 2.3 78.0 1.0
OD1 A:ASP285 2.4 87.5 1.0
OD2 A:ASP285 2.5 87.5 1.0
CG A:ASP285 2.7 87.5 1.0
C A:THR287 3.3 81.9 1.0
CG A:ASP288 3.6 78.0 1.0
N A:ASP288 3.9 78.0 1.0
CA A:ASP288 4.0 78.0 1.0
CB A:ASP285 4.1 87.5 1.0
N A:THR287 4.2 81.9 1.0
CA A:THR287 4.2 81.9 1.0
CB A:ASP288 4.3 78.0 1.0
OD2 A:ASP288 4.5 78.0 1.0
O A:ASP285 4.6 87.5 1.0
C A:ASP285 4.6 87.5 1.0
N A:LEU329 4.8 70.4 1.0
CA A:ASP285 4.8 87.5 1.0
CA A:ALA328 5.0 77.3 1.0

Calcium binding site 2 out of 7 in 7uab

Go back to Calcium Binding Sites List in 7uab
Calcium binding site 2 out of 7 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca705

b:74.5
occ:1.00
 OD1 A:ASP422 2.3 75.7 1.0
O A:TYR313 2.3 71.3 1.0
OE1 A:GLU272 2.3 80.7 1.0
OG1 A:THR303 2.3 77.7 1.0
O A:THR270 2.3 78.4 1.0
OD2 A:ASP422 2.5 75.7 1.0
CG A:ASP422 2.7 75.7 1.0
CB A:THR303 3.2 77.7 1.0
C A:TYR313 3.5 71.3 1.0
C A:THR270 3.5 78.4 1.0
CD A:GLU272 3.5 80.7 1.0
N A:TYR313 3.8 71.3 1.0
N A:THR303 4.1 77.7 1.0
CA A:TYR313 4.1 71.3 1.0
CB A:ASP301 4.1 76.5 1.0
CG2 A:THR303 4.2 77.7 1.0
CB A:ASP422 4.2 75.7 1.0
OD1 A:ASP423 4.2 76.3 1.0
CA A:THR270 4.3 78.4 1.0
CA A:THR303 4.3 77.7 1.0
CG A:GLU272 4.3 80.7 1.0
CB A:PHE271 4.4 78.4 1.0
N A:PHE271 4.4 78.4 1.0
CB A:THR270 4.5 78.4 1.0
OE2 A:GLU272 4.5 80.7 1.0
N A:PHE314 4.5 74.2 1.0
OD2 A:ASP301 4.6 76.5 1.0
CB A:TYR313 4.6 71.3 1.0
CA A:PHE271 4.7 78.4 1.0
C A:PHE271 4.7 78.4 1.0
N A:GLU272 4.8 80.7 1.0
CG A:ASP301 4.8 76.5 1.0
N A:ASP423 4.8 76.3 1.0
CA A:PHE314 4.9 74.2 1.0
N A:HIS302 4.9 75.2 1.0
CA A:ASP422 5.0 75.7 1.0
CD2 A:PHE271 5.0 78.4 1.0
CG A:ASP423 5.0 76.3 1.0

Calcium binding site 3 out of 7 in 7uab

Go back to Calcium Binding Sites List in 7uab
Calcium binding site 3 out of 7 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Ca704

b:76.0
occ:1.00
 OD1 D:ASP422 2.3 79.2 1.0
O D:TYR313 2.3 77.1 1.0
OG1 D:THR303 2.3 79.8 1.0
O D:THR270 2.3 80.8 1.0
OE1 D:GLU272 2.3 80.1 1.0
OD2 D:ASP422 2.5 79.2 1.0
CG D:ASP422 2.7 79.2 1.0
CB D:THR303 3.1 79.8 1.0
C D:TYR313 3.4 77.1 1.0
C D:THR270 3.5 80.8 1.0
CD D:GLU272 3.5 80.1 1.0
N D:TYR313 3.9 77.1 1.0
N D:THR303 4.1 79.8 1.0
CG2 D:THR303 4.1 79.8 1.0
CA D:THR270 4.2 80.8 1.0
CA D:TYR313 4.2 77.1 1.0
CA D:THR303 4.2 79.8 1.0
CB D:ASP422 4.2 79.2 1.0
CB D:THR270 4.3 80.8 1.0
CB D:ASP301 4.3 80.4 1.0
OD1 D:ASP423 4.3 79.3 1.0
CG D:GLU272 4.3 80.1 1.0
OE2 D:GLU272 4.4 80.1 1.0
OD2 D:ASP301 4.4 80.4 1.0
N D:PHE271 4.5 80.5 1.0
N D:PHE314 4.5 81.2 1.0
CB D:PHE271 4.6 80.5 1.0
CB D:TYR313 4.7 77.1 1.0
CG D:ASP301 4.8 80.4 1.0
N D:GLU272 4.8 80.1 1.0
N D:ASP423 4.8 79.3 1.0
CA D:PHE271 4.8 80.5 1.0
C D:PHE271 4.8 80.5 1.0
CA D:PHE314 4.8 81.2 1.0
CA D:ASP422 4.9 79.2 1.0
N D:HIS302 5.0 78.7 1.0
CD2 D:PHE271 5.0 80.5 1.0

Calcium binding site 4 out of 7 in 7uab

Go back to Calcium Binding Sites List in 7uab
Calcium binding site 4 out of 7 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Ca703

b:86.2
occ:1.00
 OD1 E:ASP288 2.3 76.2 1.0
OD1 E:ASP285 2.3 85.6 1.0
OD2 E:ASP285 2.4 85.6 1.0
O E:THR287 2.4 79.2 1.0
O E:GLY282 2.4 78.9 1.0
CG E:ASP285 2.7 85.6 1.0
C E:GLY282 3.4 78.9 1.0
C E:THR287 3.5 79.2 1.0
CG E:ASP288 3.5 76.2 1.0
N E:GLY282 3.7 78.9 1.0
CA E:GLY282 3.8 78.9 1.0
CA E:ASP288 4.0 76.2 1.0
N E:ASP288 4.1 76.2 1.0
CB E:ASP285 4.2 85.6 1.0
CB E:ASP288 4.3 76.2 1.0
OD2 E:ASP288 4.4 76.2 1.0
CB E:GLN281 4.5 72.1 1.0
N E:THR283 4.5 80.7 1.0
OE1 E:GLN281 4.5 72.1 1.0
C E:GLN281 4.5 72.1 1.0
O E:LEU329 4.6 71.2 1.0
CA E:THR287 4.6 79.2 1.0
N E:THR287 4.6 79.2 1.0
N E:LEU329 4.7 71.2 1.0
CA E:GLN281 4.9 72.1 1.0

Calcium binding site 5 out of 7 in 7uab

Go back to Calcium Binding Sites List in 7uab
Calcium binding site 5 out of 7 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Ca705

b:67.5
occ:1.00
 OG1 E:THR303 2.3 69.4 1.0
O E:TYR313 2.3 67.4 1.0
OD1 E:ASP422 2.3 67.4 1.0
OE1 E:GLU272 2.3 72.7 1.0
O E:THR270 2.3 69.5 1.0
OD2 E:ASP422 2.5 67.4 1.0
CG E:ASP422 2.8 67.4 1.0
CB E:THR303 3.2 69.4 1.0
CD E:GLU272 3.5 72.7 1.0
C E:TYR313 3.5 67.4 1.0
C E:THR270 3.5 69.5 1.0
N E:TYR313 4.0 67.4 1.0
N E:THR303 4.1 69.4 1.0
CG2 E:THR303 4.2 69.4 1.0
CG E:GLU272 4.2 72.7 1.0
OD1 E:ASP423 4.2 72.7 1.0
CA E:THR270 4.2 69.5 1.0
CA E:TYR313 4.3 67.4 1.0
CB E:ASP422 4.3 67.4 1.0
CA E:THR303 4.3 69.4 1.0
OD2 E:ASP301 4.3 71.8 1.0
CB E:THR270 4.3 69.5 1.0
CB E:ASP301 4.4 71.8 1.0
OE2 E:GLU272 4.5 72.7 1.0
N E:PHE314 4.5 66.6 1.0
N E:PHE271 4.5 68.2 1.0
CB E:PHE271 4.6 68.2 1.0
CA E:PHE314 4.7 66.6 1.0
CB E:TYR313 4.8 67.4 1.0
CA E:PHE271 4.8 68.2 1.0
CD2 E:PHE271 4.8 68.2 1.0
N E:GLU272 4.9 72.7 1.0
CG E:ASP301 4.9 71.8 1.0
C E:PHE271 4.9 68.2 1.0
N E:ASP423 4.9 72.7 1.0
CA E:ASP422 5.0 67.4 1.0
CG E:ASP423 5.0 72.7 1.0

Calcium binding site 6 out of 7 in 7uab

Go back to Calcium Binding Sites List in 7uab
Calcium binding site 6 out of 7 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Ca702

b:84.2
occ:1.00
 OD1 H:ASP288 2.3 73.4 1.0
OD1 H:ASP285 2.3 80.5 1.0
OD2 H:ASP285 2.4 80.5 1.0
O H:THR287 2.5 78.0 1.0
O H:GLY282 2.6 77.0 1.0
CG H:ASP285 2.7 80.5 1.0
C H:THR287 3.4 78.0 1.0
C H:GLY282 3.5 77.0 1.0
CG H:ASP288 3.5 73.4 1.0
N H:ASP288 4.1 73.4 1.0
CB H:ASP285 4.1 80.5 1.0
CA H:GLY282 4.1 77.0 1.0
CA H:ASP288 4.1 73.4 1.0
N H:GLY282 4.1 77.0 1.0
CA H:THR287 4.3 78.0 1.0
O H:ASP285 4.3 80.5 1.0
N H:THR287 4.3 78.0 1.0
OD2 H:ASP288 4.4 73.4 1.0
CB H:ASP288 4.4 73.4 1.0
N H:THR283 4.5 78.8 1.0
C H:ASP285 4.5 80.5 1.0
N H:LEU329 4.7 70.2 1.0
C H:GLN281 4.8 70.5 1.0
CA H:ASP285 4.8 80.5 1.0
CA H:THR283 4.8 78.8 1.0
OE1 H:GLN281 4.8 70.5 1.0
CB H:GLN281 4.8 70.5 1.0
O H:LEU329 4.9 70.2 1.0
N H:ASP285 5.0 80.5 1.0

Calcium binding site 7 out of 7 in 7uab

Go back to Calcium Binding Sites List in 7uab
Calcium binding site 7 out of 7 in the Human Pro-Meprin Alpha (Zymogen State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Human Pro-Meprin Alpha (Zymogen State) within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Ca704

b:70.2
occ:1.00
 OE1 H:GLU272 2.3 69.9 1.0
OG1 H:THR303 2.3 70.7 1.0
OD1 H:ASP422 2.3 66.6 1.0
O H:TYR313 2.3 66.0 1.0
O H:THR270 2.4 71.2 1.0
OD2 H:ASP422 2.5 66.6 1.0
CG H:ASP422 2.7 66.6 1.0
CB H:THR303 3.2 70.7 1.0
CD H:GLU272 3.5 69.9 1.0
C H:TYR313 3.5 66.0 1.0
C H:THR270 3.6 71.2 1.0
OD2 H:ASP301 3.7 72.6 1.0
N H:TYR313 3.8 66.0 1.0
N H:THR303 4.0 70.7 1.0
CB H:ASP301 4.1 72.6 1.0
CG H:GLU272 4.2 69.9 1.0
CA H:TYR313 4.2 66.0 1.0
CA H:THR303 4.2 70.7 1.0
CG2 H:THR303 4.2 70.7 1.0
CB H:ASP422 4.2 66.6 1.0
OD1 H:ASP423 4.3 71.8 1.0
CG H:ASP301 4.4 72.6 1.0
CA H:THR270 4.4 71.2 1.0
OE2 H:GLU272 4.5 69.9 1.0
N H:PHE314 4.5 64.3 1.0
CB H:PHE271 4.5 67.4 1.0
N H:PHE271 4.6 67.4 1.0
CB H:THR270 4.6 71.2 1.0
C H:PHE271 4.7 67.4 1.0
CA H:PHE271 4.8 67.4 1.0
N H:GLU272 4.8 69.9 1.0
CB H:TYR313 4.8 66.0 1.0
CA H:PHE314 4.8 64.3 1.0
C H:GLY312 4.9 73.5 1.0
CG H:ASP423 5.0 71.8 1.0
N H:HIS302 5.0 70.4 1.0
N H:ASP423 5.0 71.8 1.0
CA H:ASP422 5.0 66.6 1.0

Reference:

C.Bayly-Jones, C.J.Lupton, C.Fritz, H.Venugopal, D.Ramsbeck, M.Wermann, C.Jager, A.De Marco, S.Schilling, D.Schlenzig, J.C.Whisstock. Helical Ultrastructure of the Metalloprotease Meprin Alpha in Complex with A Small Molecule Inhibitor. Nat Commun V. 13 6178 2022.
ISSN: ESSN 2041-1723
PubMed: 36261433
DOI: 10.1038/S41467-022-33893-7
Page generated: Thu Jul 10 01:30:12 2025

Last articles

Mn in 2B7Y
Mn in 2B97
Mn in 2BAN
Mn in 2B7O
Mn in 2AYL
Mn in 2B2K
Mn in 2B5J
Mn in 2B51
Mn in 2AXT
Mn in 2AW9
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy