Calcium in PDB 8foa: Cryo-Em Structure of Human TRPV6 in Complex with the Natural Phytoestrogen Genistein

The structure of Cryo-Em Structure of Human TRPV6 in Complex with the Natural Phytoestrogen Genistein also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of Human TRPV6 in Complex with the Natural Phytoestrogen Genistein (pdb code 8foa). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Cryo-Em Structure of Human TRPV6 in Complex with the Natural Phytoestrogen Genistein, PDB code: 8foa:

Calcium binding site 1 out of 1 in the Cryo-Em Structure of Human TRPV6 in Complex with the Natural Phytoestrogen Genistein


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Human TRPV6 in Complex with the Natural Phytoestrogen Genistein within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca815 b:46.6 occ:1.00 OD2 C:ASP542 2.5 20.7 1.0 OD2 B:ASP542 2.5 28.4 1.0 OD2 A:ASP542 2.5 21.4 1.0 OD1 B:ASP542 2.6 28.4 1.0 OD1 C:ASP542 2.6 20.7 1.0 OD2 D:ASP542 2.6 28.0 1.0 OD1 A:ASP542 2.7 21.4 1.0 OD1 D:ASP542 2.8 28.0 1.0 CG C:ASP542 2.9 20.7 1.0 CG B:ASP542 2.9 28.4 1.0 CG A:ASP542 2.9 21.4 1.0 CG D:ASP542 3.0 28.0 1.0 CB C:ASP542 4.3 20.7 1.0 CB B:ASP542 4.3 28.4 1.0 CB A:ASP542 4.4 21.4 1.0 CB D:ASP542 4.5 28.0 1.0 N B:ASP542 4.9 28.4 1.0 N C:ASP542 4.9 20.7 1.0

A.Neuberger, Y.A.Trofimov, M.V.Yelshanskaya, K.D.Nadezhdin, N.A.Krylov, R.G.Efremov, A.I.Sobolevsky. Structural Mechanism of Human Oncochannel TRPV6 Inhibition By the Natural Phytoestrogen Genistein. Nat Commun V. 14 2659 2023.
ISSN: ESSN 2041-1723
PubMed: 37160865
DOI: 10.1038/S41467-023-38352-5