Calcium in PDB 8gvx: Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2

The structure of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 (pdb code 8gvx). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2, PDB code: 8gvx:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca804 b:208.3 occ:1.00 OD1 B:ASN436 2.5 184.9 1.0 OD2 B:ASP439 2.7 181.6 1.0 OE2 B:GLU418 2.7 208.0 1.0 OE1 B:GLU421 3.1 219.5 1.0 CD B:GLU418 3.5 208.0 1.0 OE1 B:GLU418 3.5 208.0 1.0 CG B:ASN436 3.8 184.9 1.0 CG B:ASP439 3.8 181.6 1.0 CD B:GLU421 3.9 219.5 1.0 NH2 B:ARG492 4.0 153.7 1.0 OE2 B:GLU421 4.3 219.5 1.0 CB B:ASP439 4.5 181.6 1.0 ND2 B:ASN436 4.6 184.9 1.0 CA B:ASN436 4.7 184.9 1.0 CB B:ASN436 4.7 184.9 1.0 OD1 B:ASP439 4.7 181.6 1.0 CE1 B:TYR430 4.8 202.4 1.0 CG B:GLU421 4.9 219.5 1.0 CG B:GLU418 4.9 208.0 1.0

Calcium binding site 2 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca804 b:208.3 occ:1.00 OD1 A:ASN436 2.5 184.9 1.0 OD2 A:ASP439 2.7 181.6 1.0 OE2 A:GLU418 2.7 208.0 1.0 OE1 A:GLU421 3.1 219.5 1.0 CD A:GLU418 3.5 208.0 1.0 OE1 A:GLU418 3.5 208.0 1.0 CG A:ASN436 3.8 184.9 1.0 CG A:ASP439 3.8 181.6 1.0 CD A:GLU421 3.9 219.5 1.0 NH2 A:ARG492 4.0 153.7 1.0 OE2 A:GLU421 4.3 219.5 1.0 CB A:ASP439 4.5 181.6 1.0 ND2 A:ASN436 4.6 184.9 1.0 CA A:ASN436 4.7 184.9 1.0 CB A:ASN436 4.7 184.9 1.0 OD1 A:ASP439 4.7 181.6 1.0 CE1 A:TYR430 4.8 202.4 1.0 CG A:GLU421 4.9 219.5 1.0 CG A:GLU418 4.9 208.0 1.0

Calcium binding site 3 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca804 b:208.3 occ:1.00 OD1 C:ASN436 2.5 184.9 1.0 OD2 C:ASP439 2.7 181.6 1.0 OE2 C:GLU418 2.7 208.0 1.0 OE1 C:GLU421 3.1 219.5 1.0 CD C:GLU418 3.5 208.0 1.0 OE1 C:GLU418 3.5 208.0 1.0 CG C:ASN436 3.8 184.9 1.0 CG C:ASP439 3.8 181.6 1.0 CD C:GLU421 3.9 219.5 1.0 NH2 C:ARG492 4.0 153.7 1.0 OE2 C:GLU421 4.3 219.5 1.0 CB C:ASP439 4.5 181.6 1.0 ND2 C:ASN436 4.6 184.9 1.0 CA C:ASN436 4.7 184.9 1.0 CB C:ASN436 4.7 184.9 1.0 OD1 C:ASP439 4.7 181.6 1.0 CE1 C:TYR430 4.8 202.4 1.0 CG C:GLU421 4.9 219.5 1.0 CG C:GLU418 4.9 208.0 1.0

Calcium binding site 4 out of 4 in the Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of the Human TRPC5 Ion Channel in Complex with G Alpha I3 Subunits, CLASS2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca804 b:208.3 occ:1.00 OD1 D:ASN436 2.5 184.9 1.0 OD2 D:ASP439 2.7 181.6 1.0 OE2 D:GLU418 2.7 208.0 1.0 OE1 D:GLU421 3.1 219.5 1.0 CD D:GLU418 3.5 208.0 1.0 OE1 D:GLU418 3.5 208.0 1.0 CG D:ASN436 3.8 184.9 1.0 CG D:ASP439 3.8 181.6 1.0 CD D:GLU421 3.9 219.5 1.0 NH2 D:ARG492 4.0 153.7 1.0 OE2 D:GLU421 4.3 219.5 1.0 CB D:ASP439 4.5 181.6 1.0 ND2 D:ASN436 4.6 184.9 1.0 CA D:ASN436 4.7 184.9 1.0 CB D:ASN436 4.7 184.9 1.0 OD1 D:ASP439 4.7 181.6 1.0 CE1 D:TYR430 4.8 202.4 1.0 CG D:GLU421 4.9 219.5 1.0 CG D:GLU418 4.9 208.0 1.0

J.Won, J.Kim, H.Jeong, J.Kim, S.Feng, B.Jeong, M.Kwak, J.Ko, W.Im, I.So, H.H.Lee. Molecular Architecture of the G Alpha I -Bound TRPC5 Ion Channel. Nat Commun V. 14 2550 2023.
ISSN: ESSN 2041-1723
PubMed: 37137991
DOI: 10.1038/S41467-023-38281-3