Calcium in PDB 8si6: Cryo-Em Structure of TRPM7 in MSP2N2 Nanodisc in Complex with Agonist Naltriben in Closed State

All present enzymatic activity of Cryo-Em Structure of TRPM7 in MSP2N2 Nanodisc in Complex with Agonist Naltriben in Closed State:
2.7.11.1;

The binding sites of Calcium atom in the Cryo-Em Structure of TRPM7 in MSP2N2 Nanodisc in Complex with Agonist Naltriben in Closed State (pdb code 8si6). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Cryo-Em Structure of TRPM7 in MSP2N2 Nanodisc in Complex with Agonist Naltriben in Closed State, PDB code: 8si6:

Calcium binding site 1 out of 1 in the Cryo-Em Structure of TRPM7 in MSP2N2 Nanodisc in Complex with Agonist Naltriben in Closed State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of TRPM7 in MSP2N2 Nanodisc in Complex with Agonist Naltriben in Closed State within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1317 b:66.5 occ:1.00 HA3 C:GLY1046 3.3 33.4 1.0 HA3 A:GLY1046 3.5 33.4 1.0 HA3 D:GLY1046 3.5 38.7 1.0 HA3 B:GLY1046 3.5 37.3 1.0 HA2 C:GLY1046 3.5 33.4 1.0 HA2 D:GLY1046 3.6 38.7 1.0 HA2 A:GLY1046 3.6 33.4 1.0 HA2 B:GLY1046 3.7 37.3 1.0 CA C:GLY1046 3.9 33.4 1.0 CA D:GLY1046 4.0 38.7 1.0 CA A:GLY1046 4.0 33.4 1.0 CA B:GLY1046 4.1 37.3 1.0 O C:GLY1046 4.5 33.4 1.0 O D:GLY1046 4.6 38.7 1.0 O A:GLY1046 4.6 33.4 1.0 O B:GLY1046 4.7 37.3 1.0 C C:GLY1046 4.7 33.4 1.0 C D:GLY1046 4.9 38.7 1.0 C A:GLY1046 4.9 33.4 1.0 N C:GLY1046 4.9 33.4 1.0 C B:GLY1046 4.9 37.3 1.0

K.D.Nadezhdin, L.Correia, C.Narangoda, D.S.Patel, A.Neuberger, T.Gudermann, M.G.Kurnikova, V.Chubanov, A.I.Sobolevsky. Structural Mechanisms of TRPM7 Activation and Inhibition Nat Commun.
ISSN: ESSN 2041-1723