Calcium in PDB 8sli: Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1

The binding sites of Calcium atom in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 (pdb code 8sli). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1, PDB code: 8sli:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1201 b:30.0 occ:1.00 OD1 A:ASP350 2.4 274.2 1.0 OE1 A:GLN225 2.5 293.7 1.0 O A:ASP350 2.6 274.2 1.0 CD A:GLN225 2.9 293.7 1.0 OE2 A:GLU354 3.0 30.0 1.0 OE1 A:GLU354 3.4 30.0 1.0 CG A:GLN225 3.5 293.7 1.0 CB A:GLN225 3.5 293.7 1.0 C A:ASP350 3.5 274.2 1.0 CD A:GLU354 3.6 30.0 1.0 NE2 A:GLN225 3.6 293.7 1.0 CG A:ASP350 3.6 274.2 1.0 CA A:ASP350 3.8 274.2 1.0 CB A:ASP350 4.3 274.2 1.0 CB A:ASP353 4.5 252.7 1.0 OD2 A:ASP350 4.6 274.2 1.0 O A:GLN349 4.7 268.3 1.0 N A:TYR351 4.8 274.6 1.0 N A:ASP353 4.8 252.7 1.0 CA A:GLN225 4.9 293.7 1.0

Calcium binding site 2 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1202 b:236.4 occ:1.00 OD2 A:ASP810 2.5 217.4 1.0 OD1 A:ASN807 2.5 233.5 1.0 NE2 A:GLN784 2.5 190.1 1.0 CG A:ASN807 3.6 233.5 1.0 CG A:ASP810 3.7 217.4 1.0 CD A:GLN784 3.7 190.1 1.0 OE1 A:GLN784 4.2 190.1 1.0 ND2 A:ASN807 4.4 233.5 1.0 CA A:ASN807 4.4 233.5 1.0 OD1 A:ASP810 4.4 217.4 1.0 CB A:ASN807 4.6 233.5 1.0 CB A:ASP810 4.6 217.4 1.0 N A:ASN807 4.7 233.5 1.0 OD2 A:ASP804 4.7 248.5 1.0 CG A:GLN784 4.9 190.1 1.0 O A:TRP806 4.9 230.8 1.0

Calcium binding site 3 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:30.0 occ:1.00 OD1 D:ASP350 2.4 274.2 1.0 OE1 D:GLN225 2.5 293.7 1.0 O D:ASP350 2.6 274.2 1.0 CD D:GLN225 2.9 293.7 1.0 OE2 D:GLU354 3.0 30.0 1.0 OE1 D:GLU354 3.4 30.0 1.0 CG D:GLN225 3.5 293.7 1.0 CB D:GLN225 3.5 293.7 1.0 C D:ASP350 3.5 274.2 1.0 CD D:GLU354 3.6 30.0 1.0 NE2 D:GLN225 3.6 293.7 1.0 CG D:ASP350 3.6 274.2 1.0 CA D:ASP350 3.8 274.2 1.0 CB D:ASP350 4.3 274.2 1.0 CB D:ASP353 4.5 252.7 1.0 OD2 D:ASP350 4.6 274.2 1.0 O D:GLN349 4.7 268.3 1.0 N D:TYR351 4.8 274.6 1.0 N D:ASP353 4.8 252.7 1.0 CA D:GLN225 4.9 293.7 1.0

Calcium binding site 4 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1202 b:236.4 occ:1.00 OD2 D:ASP810 2.5 217.4 1.0 OD1 D:ASN807 2.5 233.5 1.0 NE2 D:GLN784 2.5 190.1 1.0 CG D:ASN807 3.6 233.5 1.0 CG D:ASP810 3.7 217.4 1.0 CD D:GLN784 3.7 190.1 1.0 OE1 D:GLN784 4.2 190.1 1.0 ND2 D:ASN807 4.4 233.5 1.0 CA D:ASN807 4.4 233.5 1.0 OD1 D:ASP810 4.4 217.4 1.0 CB D:ASN807 4.6 233.5 1.0 CB D:ASP810 4.6 217.4 1.0 N D:ASN807 4.7 233.5 1.0 OD2 D:ASP804 4.7 248.5 1.0 CG D:GLN784 4.9 190.1 1.0 O D:TRP806 4.9 230.8 1.0

Calcium binding site 5 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1201 b:30.0 occ:1.00 OD1 C:ASP350 2.4 274.2 1.0 OE1 C:GLN225 2.5 293.7 1.0 O C:ASP350 2.6 274.2 1.0 CD C:GLN225 2.9 293.7 1.0 OE2 C:GLU354 3.0 30.0 1.0 OE1 C:GLU354 3.4 30.0 1.0 CG C:GLN225 3.5 293.7 1.0 CB C:GLN225 3.5 293.7 1.0 C C:ASP350 3.5 274.2 1.0 CD C:GLU354 3.6 30.0 1.0 NE2 C:GLN225 3.6 293.7 1.0 CG C:ASP350 3.6 274.2 1.0 CA C:ASP350 3.8 274.2 1.0 CB C:ASP350 4.3 274.2 1.0 CB C:ASP353 4.5 252.7 1.0 OD2 C:ASP350 4.6 274.2 1.0 O C:GLN349 4.7 268.3 1.0 N C:TYR351 4.8 274.6 1.0 N C:ASP353 4.8 252.7 1.0 CA C:GLN225 4.9 293.7 1.0

Calcium binding site 6 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1202 b:236.4 occ:1.00 OD2 C:ASP810 2.5 217.4 1.0 OD1 C:ASN807 2.5 233.5 1.0 NE2 C:GLN784 2.5 190.1 1.0 CG C:ASN807 3.6 233.5 1.0 CG C:ASP810 3.7 217.4 1.0 CD C:GLN784 3.7 190.1 1.0 OE1 C:GLN784 4.2 190.1 1.0 ND2 C:ASN807 4.4 233.5 1.0 CA C:ASN807 4.4 233.5 1.0 OD1 C:ASP810 4.4 217.4 1.0 CB C:ASN807 4.6 233.5 1.0 CB C:ASP810 4.6 217.4 1.0 N C:ASN807 4.7 233.5 1.0 OD2 C:ASP804 4.7 248.5 1.0 CG C:GLN784 4.9 190.1 1.0 O C:TRP806 4.9 230.8 1.0

Calcium binding site 7 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1201 b:30.0 occ:1.00 OD1 B:ASP350 2.4 274.2 1.0 OE1 B:GLN225 2.5 293.7 1.0 O B:ASP350 2.6 274.2 1.0 CD B:GLN225 2.9 293.7 1.0 OE2 B:GLU354 3.0 30.0 1.0 OE1 B:GLU354 3.4 30.0 1.0 CG B:GLN225 3.5 293.7 1.0 CB B:GLN225 3.5 293.7 1.0 C B:ASP350 3.5 274.2 1.0 CD B:GLU354 3.6 30.0 1.0 NE2 B:GLN225 3.6 293.7 1.0 CG B:ASP350 3.6 274.2 1.0 CA B:ASP350 3.8 274.2 1.0 CB B:ASP350 4.3 274.2 1.0 CB B:ASP353 4.5 252.7 1.0 OD2 B:ASP350 4.6 274.2 1.0 O B:GLN349 4.7 268.3 1.0 N B:TYR351 4.8 274.6 1.0 N B:ASP353 4.8 252.7 1.0 CA B:GLN225 4.9 293.7 1.0

Calcium binding site 8 out of 8 in the Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Cryo-Em Structure of the Rat TRPM5 Channel in 2MM Calcium, High-1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1202 b:236.4 occ:1.00 OD2 B:ASP810 2.5 217.4 1.0 OD1 B:ASN807 2.5 233.5 1.0 NE2 B:GLN784 2.5 190.1 1.0 CG B:ASN807 3.6 233.5 1.0 CG B:ASP810 3.7 217.4 1.0 CD B:GLN784 3.7 190.1 1.0 OE1 B:GLN784 4.2 190.1 1.0 ND2 B:ASN807 4.4 233.5 1.0 CA B:ASN807 4.4 233.5 1.0 OD1 B:ASP810 4.4 217.4 1.0 CB B:ASN807 4.6 233.5 1.0 CB B:ASP810 4.6 217.4 1.0 N B:ASN807 4.7 233.5 1.0 OD2 B:ASP804 4.7 248.5 1.0 CG B:GLN784 4.9 190.1 1.0 O B:TRP806 4.9 230.8 1.0

S.Karuppan, L.G.Schrag, C.Pastrano, A.Jara-Oseguera, L.Zubcevic. Structural Dynamics at Cytosolic Inter-Protomer Interfaces Control Gating of A Mammalian TRPM5 Channel Proc.Natl.Acad.Sci.Usa V. 121 2024.
ISSN: ESSN 1091-6490
DOI: 10.1073/PNAS.2403333121