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Calcium in PDB 8v2h: Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.

Other elements in 8v2h:

The structure of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. also contains other interesting chemical elements:

Potassium (K) 4 atoms

Calcium Binding Sites:

The binding sites of Calcium atom in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. (pdb code 8v2h). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145., PDB code: 8v2h:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in 8v2h

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Calcium binding site 1 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Ca201

b:74.2
occ:1.00
 O E:THR26 2.4 69.9 1.0
OD1 E:ASP20 2.4 73.8 1.0
OD1 E:ASP22 2.5 84.2 1.0
CB E:ASP24 3.2 70.3 1.0
OE2 E:GLU31 3.5 71.6 1.0
C E:THR26 3.6 70.9 1.0
CG E:ASP22 3.6 83.0 1.0
CG E:ASP20 3.6 74.2 1.0
N E:ASP24 3.8 70.9 1.0
OD2 E:ASP22 4.0 82.7 1.0
CA E:ASP20 4.1 71.6 1.0
CA E:ASP24 4.1 73.3 1.0
CA E:ILE27 4.1 74.6 1.0
N E:ILE27 4.3 75.0 1.0
N E:LYS21 4.3 77.3 1.0
CG E:ASP24 4.4 72.8 1.0
CD E:GLU31 4.4 73.7 1.0
OE1 E:GLU31 4.4 74.0 1.0
OD2 E:ASP24 4.4 70.6 1.0
CB E:ASP20 4.4 71.2 1.0
N E:ASP22 4.5 84.1 1.0
OD2 E:ASP20 4.5 71.1 1.0
N E:THR26 4.5 69.5 1.0
C E:ASP20 4.5 69.1 1.0
O E:PHE19 4.6 62.6 1.0
N E:THR28 4.7 76.0 1.0
CA E:THR26 4.7 71.3 1.0
N E:GLY23 4.7 75.2 1.0
C E:ASP24 4.8 70.9 1.0
C E:ILE27 4.8 72.9 1.0
CB E:ASP22 4.9 82.2 1.0
CG2 E:THR28 4.9 76.7 1.0
N E:GLY25 5.0 64.2 1.0
CG2 E:THR26 5.0 69.0 1.0

Calcium binding site 2 out of 8 in 8v2h

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Calcium binding site 2 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Ca202

b:73.0
occ:1.00
 O E:THR62 2.4 72.5 1.0
OD1 E:ASP64 2.5 72.0 1.0
CG E:ASP64 2.7 72.9 1.0
OD2 E:ASP64 2.7 71.7 1.0
OD1 E:ASN60 3.1 77.0 1.0
C E:THR62 3.2 72.3 1.0
CB E:ASP58 3.3 75.7 1.0
CG2 E:THR62 3.3 70.1 1.0
ND2 E:ASN60 3.4 79.7 1.0
N E:ASP64 3.6 72.9 1.0
CG E:ASN60 3.7 80.5 1.0
C E:ILE63 3.7 72.2 1.0
N E:ILE63 3.8 73.6 1.0
CB E:ASP64 3.9 73.0 1.0
CA E:ILE63 3.9 73.5 1.0
CG E:ASP58 4.0 76.8 1.0
CA E:THR62 4.1 72.2 1.0
OD2 E:ASP58 4.1 73.8 1.0
OE2 E:GLU67 4.2 73.1 1.0
CA E:ASP64 4.2 73.2 1.0
CB E:THR62 4.3 72.1 1.0
OG1 E:THR26 4.3 72.6 1.0
OD1 E:ASP56 4.3 78.1 1.0
O E:ILE63 4.3 67.6 1.0
N E:THR62 4.3 73.2 1.0
CA E:ASP58 4.6 75.8 1.0
N E:ASP58 4.7 73.5 1.0
OG1 E:THR62 4.7 72.5 1.0
OD1 E:ASP58 4.8 74.7 1.0

Calcium binding site 3 out of 8 in 8v2h

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Calcium binding site 3 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Ca201

b:87.1
occ:1.00
 OE1 F:GLU31 2.3 76.9 1.0
O F:THR26 2.3 69.4 1.0
N F:THR28 2.4 78.2 1.0
C F:THR26 2.6 72.8 1.0
CG2 F:THR28 2.7 75.6 1.0
N F:ILE27 2.9 74.5 1.0
OG1 F:THR26 2.9 69.5 1.0
C F:ILE27 2.9 73.2 1.0
CA F:ILE27 3.0 73.6 1.0
OD2 F:ASP24 3.0 69.7 1.0
OG1 F:THR28 3.1 74.3 1.0
CB F:THR28 3.2 77.1 1.0
CD F:GLU31 3.3 77.1 1.0
CA F:THR28 3.3 79.2 1.0
CB F:THR26 3.5 69.1 1.0
CA F:THR26 3.6 72.9 1.0
OE2 F:GLU31 3.6 75.2 1.0
CG F:ASP24 3.8 71.0 1.0
O F:ILE27 4.0 73.8 1.0
OG1 F:THR62 4.1 71.2 1.0
N F:THR26 4.3 72.7 1.0
OD1 F:ASP24 4.5 70.7 1.0
CB F:ILE27 4.5 74.5 1.0
CB F:ASP24 4.5 69.1 1.0
C F:THR28 4.6 78.1 1.0
CG F:GLU31 4.6 76.8 1.0
O F:THR28 4.9 75.5 1.0
CG2 F:THR26 5.0 68.0 1.0

Calcium binding site 4 out of 8 in 8v2h

Go back to Calcium Binding Sites List in 8v2h
Calcium binding site 4 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Ca202

b:80.3
occ:1.00
 O F:THR62 2.4 78.2 1.0
OD1 F:ASP56 2.5 78.5 1.0
OE2 F:GLU67 2.6 75.9 1.0
OD1 F:ASN60 2.7 76.6 1.0
CB F:ASP58 2.9 77.2 1.0
OE1 F:GLU67 2.9 74.7 1.0
CD F:GLU67 3.1 75.4 1.0
N F:ASP58 3.2 75.9 1.0
CA F:ASP58 3.5 76.2 1.0
CG F:ASP56 3.6 78.1 1.0
OD2 F:ASP64 3.6 72.8 1.0
C F:THR62 3.6 78.7 1.0
N F:GLY59 3.7 76.0 1.0
CG F:ASN60 3.7 80.2 1.0
CA F:ASP56 3.8 76.5 1.0
N F:ALA57 3.9 75.3 1.0
C F:ASP56 4.0 80.4 1.0
CG F:ASP64 4.0 76.0 1.0
C F:ASP58 4.1 75.3 1.0
CG F:ASP58 4.1 78.7 1.0
ND2 F:ASN60 4.1 79.7 1.0
OD1 F:ASP64 4.2 74.3 1.0
N F:ASN60 4.2 80.8 1.0
CB F:ASP56 4.3 75.9 1.0
C F:ALA57 4.3 72.5 1.0
N F:THR62 4.3 78.3 1.0
OD1 F:ASP58 4.4 77.2 1.0
N F:ASP64 4.4 77.0 1.0
CA F:ILE63 4.5 76.9 1.0
N F:ILE63 4.5 78.2 1.0
OD2 F:ASP56 4.5 78.1 1.0
CA F:THR62 4.6 77.9 1.0
O F:ASP56 4.6 81.4 1.0
CG F:GLU67 4.6 73.4 1.0
CA F:ALA57 4.7 72.6 1.0
O F:VAL55 4.7 81.7 1.0
C F:ILE63 4.8 76.9 1.0
CA F:GLY59 4.8 77.0 1.0
CB F:ASP64 4.9 76.4 1.0
N F:GLY61 4.9 71.2 1.0
CG2 F:THR62 4.9 73.5 1.0
CB F:ASN60 4.9 79.5 1.0
C F:GLY59 5.0 79.0 1.0

Calcium binding site 5 out of 8 in 8v2h

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Calcium binding site 5 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Ca201

b:78.7
occ:1.00
 O G:THR26 2.4 71.7 1.0
N G:THR28 2.5 78.9 1.0
OG1 G:THR28 2.8 73.8 1.0
CA G:ILE27 2.8 71.2 1.0
CG G:GLU31 2.9 76.1 1.0
C G:ILE27 3.0 72.8 1.0
C G:THR26 3.0 73.9 1.0
N G:ILE27 3.2 71.8 1.0
NZ G:LYS21 3.4 74.1 1.0
CB G:THR28 3.4 77.1 1.0
CA G:THR28 3.5 77.9 1.0
CG2 G:THR28 3.6 75.0 1.0
CD G:GLU31 3.9 77.2 1.0
CB G:GLU31 3.9 75.3 1.0
CG2 G:THR26 3.9 70.5 1.0
O G:ILE27 4.1 72.0 1.0
OE2 G:GLU31 4.1 77.9 1.0
CB G:ILE27 4.2 73.9 1.0
CA G:THR26 4.3 74.6 1.0
CB G:THR26 4.4 72.2 1.0
C G:THR28 4.4 76.3 1.0
O G:THR28 4.5 75.0 1.0
OG1 G:THR62 4.5 70.1 1.0
NZ G:LYS30 4.6 74.1 1.0
CG2 G:ILE27 4.6 72.9 1.0
OD2 G:ASP24 4.6 72.1 1.0
CE G:LYS21 4.9 74.8 1.0
CG1 G:ILE27 4.9 74.4 1.0
OE1 G:GLU31 4.9 75.6 1.0
CE G:LYS30 5.0 75.1 1.0

Calcium binding site 6 out of 8 in 8v2h

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Calcium binding site 6 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Ca202

b:70.7
occ:1.00
 OD1 G:ASP64 2.4 76.2 1.0
OD1 G:ASN60 2.4 79.3 1.0
O G:THR62 2.4 74.5 1.0
CG G:ASP64 2.8 75.1 1.0
ND2 G:ASN60 2.9 82.2 1.0
CG G:ASN60 2.9 82.9 1.0
C G:THR62 3.0 74.1 1.0
OD2 G:ASP64 3.0 72.2 1.0
CG2 G:THR62 3.3 70.2 1.0
N G:ASP64 3.5 73.8 1.0
N G:ILE63 3.5 75.8 1.0
C G:ILE63 3.6 72.0 1.0
CA G:ILE63 3.7 74.9 1.0
CA G:THR62 3.9 74.3 1.0
CB G:ASP64 3.9 75.1 1.0
OE2 G:GLU67 3.9 74.6 1.0
OD1 G:ASP56 4.0 79.6 1.0
OE1 G:GLU67 4.0 74.4 1.0
N G:THR62 4.0 75.0 1.0
CB G:ASP58 4.0 79.4 1.0
CB G:THR62 4.1 72.3 1.0
CA G:ASP64 4.1 74.3 1.0
O G:ILE63 4.3 67.6 1.0
CD G:GLU67 4.3 75.3 1.0
CB G:ASN60 4.4 82.5 1.0
CG G:ASP58 4.6 81.6 1.0
OG1 G:THR62 4.7 70.1 1.0
OD1 G:ASP58 4.9 78.5 1.0
N G:ASN60 4.9 82.9 1.0

Calcium binding site 7 out of 8 in 8v2h

Go back to Calcium Binding Sites List in 8v2h
Calcium binding site 7 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Ca201

b:80.3
occ:1.00
 OE2 H:GLU31 3.0 73.9 1.0
CD H:GLU31 3.2 76.7 1.0
OE1 H:GLU31 3.2 76.6 1.0
OD1 H:ASP22 3.6 73.9 1.0
OG1 H:THR26 3.6 73.4 1.0
CG2 H:THR28 3.7 74.4 1.0
O H:THR26 3.9 72.0 1.0
NZ H:LYS30 4.0 76.4 1.0
OD2 H:ASP22 4.0 70.7 1.0
OG1 H:THR28 4.1 74.0 1.0
CG H:GLU31 4.2 75.6 1.0
CG H:ASP22 4.2 71.1 1.0
CB H:THR28 4.5 74.9 1.0
O H:GLY23 4.6 69.3 1.0
CE H:LYS30 4.6 79.4 1.0
CB H:THR26 4.6 73.7 1.0
CB H:ASP24 4.7 76.2 1.0
C H:THR26 4.7 75.1 1.0
OD2 H:ASP24 4.8 81.9 1.0
N H:THR28 4.9 78.0 1.0

Calcium binding site 8 out of 8 in 8v2h

Go back to Calcium Binding Sites List in 8v2h
Calcium binding site 8 out of 8 in the Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145.


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Cryo-Em Structure of the KCA2.2 Channel Bound to Inhibitor AP14145. within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Ca202

b:68.2
occ:1.00
 O H:THR62 2.4 74.8 1.0
OD1 H:ASN60 2.5 78.8 1.0
ND2 H:ASN60 2.8 78.9 1.0
CG H:ASN60 3.0 80.0 1.0
C H:THR62 3.0 74.8 1.0
OG1 H:THR62 3.4 73.8 1.0
CB H:ASP58 3.6 76.4 1.0
N H:ILE63 3.7 75.1 1.0
CA H:ILE63 3.8 75.8 1.0
OD1 H:ASP56 3.9 80.1 1.0
N H:ASP64 3.9 75.1 1.0
CA H:THR62 4.0 72.4 1.0
N H:THR62 4.0 73.0 1.0
C H:ILE63 4.1 71.8 1.0
OE1 H:GLU67 4.1 75.4 1.0
CG H:ASP64 4.1 78.5 1.0
OE2 H:GLU67 4.2 75.7 1.0
CG H:ASP58 4.2 79.8 1.0
CB H:THR62 4.3 73.0 1.0
OD2 H:ASP64 4.3 76.8 1.0
OD1 H:ASP64 4.3 77.8 1.0
OD1 H:ASP58 4.4 76.5 1.0
CD H:GLU67 4.5 76.8 1.0
CB H:ASN60 4.5 77.9 1.0
CB H:ASP64 4.5 75.3 1.0
N H:GLY61 4.8 74.1 1.0
CA H:ASP58 4.8 76.1 1.0
O H:ILE63 4.8 66.9 1.0
CA H:ASP64 4.8 74.0 1.0
N H:ASN60 4.9 80.0 1.0
OD2 H:ASP58 4.9 79.7 1.0
N H:ASP58 4.9 74.9 1.0

Reference:

Y.W.Nam, D.Im, A.Santa Cruz Garcia, M.L.Tringides, H.M.Nguyen, Y.Liu, R.Orfali, A.Ramanishka, G.Pintilie, C.C.Su, M.Cui, D.E.Logothetis, E.W.Yu, H.Wulff, K.G.Chandy, M.Zhang. Cryo-Em Structures of the Small-Conductance CA2+-Activated KCA2.2 Channel Nat Commun 2025.
ISSN: ESSN 2041-1723
Page generated: Thu Jul 10 07:54:43 2025

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