Calcium in PDB 8wpm: Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145

The structure of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Chlorine	(Cl)	4 atoms
Zinc	(Zn)	4 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 (pdb code 8wpm). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145, PDB code: 8wpm:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1003 b:65.8 occ:1.00 NE2 B:GLN420 2.6 115.9 1.0 OE1 B:GLN420 2.9 114.6 1.0 OD1 B:ASN435 3.1 101.9 1.0 CD B:GLN420 3.1 114.6 1.0 OD1 B:ASP438 3.7 80.9 1.0 CG B:ASN435 4.0 99.8 1.0 OE2 B:GLU417 4.1 112.2 1.0 OE1 B:GLU417 4.4 114.1 1.0 CG B:GLN420 4.6 114.2 1.0 ND2 B:ASN435 4.6 101.2 1.0 CD B:GLU417 4.7 112.0 1.0 CG B:ASP438 4.9 81.7 1.0 NH2 B:ARG491 5.0 55.2 1.0

Calcium binding site 2 out of 3 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1003 b:51.5 occ:1.00 OD1 C:ASN435 2.4 80.2 1.0 OE1 C:GLN420 2.6 103.6 1.0 OE2 C:GLU417 2.6 96.7 1.0 OE1 C:GLU417 3.0 94.3 1.0 CD C:GLU417 3.2 97.0 1.0 CD C:GLN420 3.4 103.0 1.0 CG C:ASN435 3.7 80.3 1.0 NE2 C:GLN420 3.7 102.5 1.0 OD2 C:ASP438 3.9 73.9 1.0 CG C:ASP438 4.1 71.6 1.0 ND2 C:ASN435 4.5 81.5 1.0 CE2 C:TYR429 4.6 104.9 1.0 OD1 C:ASP438 4.6 67.0 1.0 CB C:ASP438 4.6 68.7 1.0 CA C:ASN435 4.6 74.0 1.0 CB C:ASN435 4.6 75.0 1.0 CG C:GLN420 4.7 102.6 1.0 CG C:GLU417 4.7 95.8 1.0 OH C:TYR429 4.9 98.9 1.0 CB C:GLN420 5.0 102.5 1.0

Calcium binding site 3 out of 3 in the Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of the Human TRPC1/C4 Heteromer in Complex with PICO145 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1003 b:62.6 occ:1.00 OD1 D:ASN435 2.4 71.2 1.0 OE2 D:GLU417 3.1 86.4 1.0 CG D:ASN435 3.4 67.8 1.0 OE1 D:GLU417 3.5 88.3 1.0 CD D:GLU417 3.7 87.4 1.0 NH1 D:ARG491 4.1 48.3 1.0 ND2 D:ASN435 4.1 66.9 1.0 OD2 D:ASP438 4.2 60.5 1.0 CB D:ASN435 4.3 64.3 1.0 CA D:ASN435 4.3 64.8 1.0 CG D:ASP438 4.4 60.8 1.0 CB D:ASP438 4.5 58.3 1.0 NH2 D:ARG491 4.7 41.0 1.0 CZ D:ARG491 4.8 47.8 1.0 N D:ASN435 5.0 67.2 1.0 CE1 D:TYR429 5.0 100.0 1.0

J.Won, H.Jeong, H.H.Lee. Structure of A Trp Channel To Be Published.