Calcium in PDB 9asp: Human Drosha and DGCR8 in Complex with Pri-Let-7A1

All present enzymatic activity of Human Drosha and DGCR8 in Complex with Pri-Let-7A1:
3.1.26.3;

The structure of Human Drosha and DGCR8 in Complex with Pri-Let-7A1 also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Calcium atom in the Human Drosha and DGCR8 in Complex with Pri-Let-7A1 (pdb code 9asp). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Human Drosha and DGCR8 in Complex with Pri-Let-7A1, PDB code: 9asp:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the Human Drosha and DGCR8 in Complex with Pri-Let-7A1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Drosha and DGCR8 in Complex with Pri-Let-7A1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1403 b:30.0 occ:1.00 OD1 A:ASN1042 3.3 127.5 1.0 OE2 A:GLU1045 3.6 124.2 1.0 CG A:ASN1042 4.2 127.5 1.0 CD A:GLU1045 4.5 124.2 1.0 ND2 A:ASN1042 4.5 127.5 1.0 OE1 A:GLU1045 4.7 124.2 1.0 OD1 A:ASN1006 5.0 129.7 1.0

Calcium binding site 2 out of 2 in the Human Drosha and DGCR8 in Complex with Pri-Let-7A1


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Drosha and DGCR8 in Complex with Pri-Let-7A1 within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca201 b:30.0 occ:1.00 OP1 E:U24 2.4 159.9 1.0 OE2 A:GLU1222 2.5 141.2 1.0 OD1 A:ASN1184 2.8 149.4 1.0 P E:U24 3.4 159.9 1.0 O3' E:A23 3.4 153.4 1.0 OE1 A:GLN1187 3.5 140.3 1.0 CD A:GLU1222 3.6 141.2 1.0 CG A:ASN1184 3.9 149.4 1.0 OE1 A:GLU1222 4.1 141.2 1.0 OP2 E:U24 4.2 159.9 1.0 NE2 A:GLN1187 4.2 140.3 1.0 CD A:GLN1187 4.3 140.3 1.0 ND2 A:ASN1184 4.3 149.4 1.0 O5' E:U24 4.7 159.9 1.0 C3' E:A23 4.7 153.4 1.0 CG A:GLU1222 4.9 141.2 1.0 C5' E:U24 5.0 159.9 1.0 O A:VAL1182 5.0 125.2 1.0

A.Garg, L.Joshua-Tor. RNAI_PROTEIN_A1 To Be Published.