Calcium in PDB 9axf: Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent

The structure of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Calcium atom in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent (pdb code 9axf). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 7 binding sites of Calcium where determined in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent, PDB code: 9axf:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7;

Calcium binding site 1 out of 7 in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1007 b:39.9 occ:1.00 OG1 R:THR100 2.7 28.7 1.0 N R:THR145 3.5 20.6 1.0 CB R:THR100 3.6 28.7 1.0 CB R:ALA144 3.6 19.2 1.0 CB R:THR145 3.8 20.6 1.0 OD1 R:ASN102 3.9 28.6 1.0 CG2 R:THR100 3.9 28.7 1.0 OG1 R:THR145 4.0 20.6 1.0 N R:GLY146 4.0 19.8 1.0 CA R:THR145 4.1 20.6 1.0 CG1 R:VAL149 4.1 18.9 1.0 CB R:PRO39 4.2 25.6 1.0 CD R:PRO39 4.3 25.6 1.0 CG R:PRO39 4.3 25.6 1.0 CA R:ASN102 4.4 28.6 1.0 N R:PRO39 4.5 25.6 1.0 C R:ALA144 4.5 19.2 1.0 N R:ASN102 4.5 28.6 1.0 CB R:VAL149 4.5 18.9 1.0 CA R:ALA144 4.6 19.2 1.0 C R:THR145 4.6 20.6 1.0 CG2 R:VAL149 4.7 18.9 1.0 CA R:PRO39 4.8 25.6 1.0 C R:PHE38 4.9 22.5 1.0 CG R:ASN102 5.0 28.6 1.0 CA R:THR100 5.0 28.7 1.0

Calcium binding site 2 out of 7 in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1008 b:44.7 occ:1.00 NH1 R:ARG66 3.5 25.3 1.0 OG R:SER302 3.6 25.6 1.0 N R:SER303 3.7 28.9 1.0 CA R:SER302 3.8 25.6 1.0 CB R:SER302 4.1 25.6 1.0 OG R:SER303 4.1 28.9 1.0 CD R:ARG66 4.3 25.3 1.0 C R:SER302 4.3 25.6 1.0 CE1 R:PHE42 4.5 32.1 1.0 CZ R:PHE42 4.5 32.1 1.0 CZ R:ARG66 4.6 25.3 1.0 CB R:SER303 4.7 28.9 1.0 O R:SER301 4.7 22.2 1.0 CA R:SER303 4.8 28.9 1.0 NE R:ARG66 4.9 25.3 1.0 N R:SER302 4.9 25.6 1.0 CH2 R:TCR1005 5.0 19.4 1.0

Calcium binding site 3 out of 7 in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1009 b:65.6 occ:1.00 O R:GLY557 2.6 52.8 1.0 C R:GLY557 3.6 52.8 1.0 OE2 R:GLU558 4.0 52.4 1.0 CA R:GLY557 4.1 52.8 1.0 OD1 Q:ASP234 4.2 33.4 1.0 OE1 R:GLU558 4.3 52.4 1.0 CD R:GLU558 4.4 52.4 1.0 N R:GLU558 4.7 52.4 1.0

Calcium binding site 4 out of 7 in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ Q:Ca1007 b:62.6 occ:1.00 O Q:LEU87 2.4 54.4 1.0 O Q:SER84 2.5 49.7 1.0 O Q:ILE81 2.8 40.3 1.0 O Q:LEU88 3.0 54.9 1.0 O Q:ASN82 3.6 41.7 1.0 C Q:LEU87 3.6 54.4 1.0 C Q:LEU88 3.7 54.9 1.0 C Q:SER84 3.7 49.7 1.0 C Q:ILE81 3.9 40.3 1.0 C Q:ASN82 4.1 41.7 1.0 CA Q:ASN82 4.1 41.7 1.0 O Q:LEU91 4.2 57.2 1.0 CA Q:LEU88 4.4 54.9 1.0 N Q:PRO89 4.4 58.5 1.0 N Q:LEU88 4.4 54.9 1.0 CB Q:LEU88 4.5 54.9 1.0 N Q:ASN82 4.5 41.7 1.0 N Q:SER84 4.5 49.7 1.0 CA Q:PRO85 4.6 54.6 1.0 CA Q:SER84 4.6 49.7 1.0 N Q:PRO85 4.6 54.6 1.0 CA Q:PRO89 4.6 58.5 1.0 CA Q:LEU87 4.7 54.4 1.0 N Q:LEU87 4.7 54.4 1.0 CG2 Q:ILE81 4.8 40.3 1.0 C Q:PRO85 4.9 54.6 1.0 CB Q:SER84 4.9 49.7 1.0 C Q:SER83 5.0 46.1 1.0

Calcium binding site 5 out of 7 in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ Q:Ca1008 b:33.6 occ:1.00 OG1 Q:THR100 2.6 28.8 1.0 CB Q:THR100 3.6 28.8 1.0 N Q:THR145 3.6 20.9 1.0 CB Q:ALA144 3.7 19.4 1.0 CG2 Q:THR100 3.8 28.8 1.0 CB Q:THR145 3.8 20.9 1.0 OD1 Q:ASN102 3.9 29.7 1.0 OG1 Q:THR145 4.0 20.9 1.0 CD Q:PRO39 4.0 24.8 1.0 N Q:PRO39 4.1 24.8 1.0 CB Q:PRO39 4.2 24.8 1.0 N Q:GLY146 4.2 19.9 1.0 CG Q:PRO39 4.2 24.8 1.0 CA Q:THR145 4.2 20.9 1.0 CG1 Q:VAL149 4.4 19.7 1.0 CA Q:ASN102 4.5 29.7 1.0 C Q:PHE38 4.5 22.8 1.0 N Q:ASN102 4.6 29.7 1.0 CA Q:PRO39 4.6 24.8 1.0 C Q:ALA144 4.6 19.4 1.0 CA Q:ALA144 4.7 19.4 1.0 C Q:THR145 4.8 20.9 1.0 O Q:LEU37 4.9 23.1 1.0 CB Q:VAL149 4.9 19.7 1.0 CG2 Q:VAL149 4.9 19.7 1.0 CA Q:THR100 4.9 28.8 1.0 CA Q:PHE38 4.9 22.8 1.0

Calcium binding site 6 out of 7 in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ Q:Ca1009 b:46.6 occ:1.00 OG Q:SER302 3.0 25.4 1.0 CE1 Q:PHE42 3.4 29.9 1.0 CD Q:PRO274 3.8 26.6 1.0 CB Q:SER302 3.9 25.4 1.0 CZ Q:PHE42 4.1 29.9 1.0 CG Q:LEU304 4.1 27.7 1.0 CD1 Q:LEU304 4.2 27.7 1.0 CA Q:GLY273 4.2 26.1 1.0 CD1 Q:PHE42 4.3 29.9 1.0 CA Q:SER302 4.5 25.4 1.0 N Q:GLY273 4.5 26.1 1.0 CG Q:PRO274 4.5 26.6 1.0 N Q:PRO274 4.7 26.6 1.0 CB Q:LEU304 4.8 27.7 1.0 C Q:GLY273 4.9 26.1 1.0 N Q:SER303 4.9 27.1 1.0

Calcium binding site 7 out of 7 in the Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Structure of Human Calcium-Sensing Receptor in Complex with Chimeric Gq (Minigisq) Protein in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ Q:Ca1010 b:79.0 occ:1.00 O Q:GLY557 2.5 59.1 1.0 C Q:GLY557 3.3 59.1 1.0 CA Q:GLY557 4.1 59.1 1.0 N Q:GLU558 4.1 55.7 1.0 CA Q:GLU558 4.3 55.7 1.0 OD1 R:ASP234 4.4 31.8 1.0 OE1 Q:GLU558 4.5 55.7 1.0 OE2 Q:GLU558 4.5 55.7 1.0 CD Q:GLU558 4.6 55.7 1.0

H.Zuo, J.Park, A.Frangaj, J.Ye, G.Lu, J.J.Manning, W.B.Asher, Z.Lu, G.Hu, L.Wang, J.Mendez, E.Eng, Z.Zhang, X.Lin, R.Grasucci, W.A.Hendrickson, O.B.Clarke, J.A.Javitch, A.D.Conigrave, Q.R.Fan. Promiscuous G-Protein Activation By the Calcium-Sensing Receptor Nature 2024.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-024-07331-1