Calcium in PDB 9ggc: Structure of the G848S Mutant of Human Mitochondrial Dna Polymerase Gamma

All present enzymatic activity of Structure of the G848S Mutant of Human Mitochondrial Dna Polymerase Gamma:
2.7.7.7;

The binding sites of Calcium atom in the Structure of the G848S Mutant of Human Mitochondrial Dna Polymerase Gamma (pdb code 9ggc). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure of the G848S Mutant of Human Mitochondrial Dna Polymerase Gamma, PDB code: 9ggc:

Calcium binding site 1 out of 1 in the Structure of the G848S Mutant of Human Mitochondrial Dna Polymerase Gamma


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure of the G848S Mutant of Human Mitochondrial Dna Polymerase Gamma within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1301 b:15.6 occ:1.00 O1A A:DCP1302 2.0 35.8 1.0 O2G A:DCP1302 2.1 39.4 1.0 O1B A:DCP1302 2.3 34.1 1.0 O A:VAL891 2.3 32.7 1.0 OD2 A:ASP1135 2.4 41.1 1.0 OD1 A:ASP890 2.7 38.6 1.0 OD2 A:ASP890 2.8 34.5 1.0 CG A:ASP890 3.0 36.4 1.0 PA A:DCP1302 3.4 36.6 1.0 PB A:DCP1302 3.4 33.4 1.0 PG A:DCP1302 3.5 30.6 1.0 CG A:ASP1135 3.5 38.4 1.0 C A:VAL891 3.5 32.2 1.0 O3B A:DCP1302 3.7 38.2 1.0 O3A A:DCP1302 3.9 31.0 1.0 N A:VAL891 3.9 31.1 1.0 OD1 A:ASP1135 4.0 42.0 1.0 CA A:VAL891 4.2 29.7 1.0 C5' A:DCP1302 4.2 33.5 1.0 CB A:ASP890 4.3 30.4 1.0 O5' A:DCP1302 4.3 42.6 1.0 O3G A:DCP1302 4.4 36.5 1.0 C A:ASP890 4.4 32.2 1.0 O2A A:DCP1302 4.4 39.0 1.0 O1G A:DCP1302 4.4 37.8 1.0 N A:ASP892 4.5 31.4 1.0 CB A:VAL891 4.6 32.9 1.0 CB A:ASP1135 4.7 32.8 1.0 CA A:ASP892 4.8 29.8 1.0 O2B A:DCP1302 4.8 37.0 1.0 N A:SER893 4.8 25.0 1.0 CA A:ASP890 4.8 25.6 1.0

S.Valenzuela, Z.Xuefeng, M.Macao, M.Stamgren, C.Geukens, P.S.Charifson, G.Kern, E.Hoberg, L.Jenninger, A.V.Gruszczyk, S.Lee, K.A.S.Johansson, J.Miralles Fuste, Y.Shi, S.J.Kerns, L.Arabanian, G.Martinez Botella, J.Green, A.Griffin, C.Pardo Hernandez, T.A.Keating, N.G.Larsson, C.Phan, V.Posse, J.E.Jones, X.Xie, S.Giroux, C.M.Gustafsson, M.Falkenberg. Small Molecules Restore Mutant Mitochondrial Dna Polymerase Activity To Be Published 2025.
DOI: 10.1038/S41586-025-08856-9