Calcium in PDB 9iir: Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)

The structure of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) also contains other interesting chemical elements:

Bromine

(Br)

5 atoms

The binding sites of Calcium atom in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) (pdb code 9iir). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 5 binding sites of Calcium where determined in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State), PDB code: 9iir:
Jump to Calcium binding site number: 1; 2; 3; 4; 5;

Calcium binding site 1 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca602 b:97.5 occ:1.00 O A:VAL65 3.1 95.0 1.0 OE2 A:GLU67 3.2 110.5 1.0 OD1 A:ASP64 3.4 108.0 1.0 OE1 A:GLU67 3.6 108.5 1.0 CD A:GLU67 3.7 111.6 1.0 OE2 A:GLU195 3.8 96.1 1.0 OE1 A:GLU195 3.9 89.7 1.0 C A:VAL65 4.1 88.9 1.0 CD A:GLU195 4.3 92.5 1.0 CG A:ASP64 4.5 105.0 1.0 N A:VAL65 4.7 92.3 1.0 OH A:TYR233 4.8 105.0 1.0 OD2 A:ASP64 4.8 102.8 1.0 N A:ASP66 4.9 101.1 1.0 CA A:ASP66 4.9 104.5 1.0 CA A:VAL65 4.9 88.0 1.0

Calcium binding site 2 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca602 b:97.5 occ:1.00 O B:VAL65 3.1 95.0 1.0 OE2 B:GLU67 3.2 110.5 1.0 OD1 B:ASP64 3.4 108.0 1.0 OE1 B:GLU67 3.6 108.5 1.0 CD B:GLU67 3.7 111.6 1.0 OE2 B:GLU195 3.8 96.1 1.0 OE1 B:GLU195 3.9 89.7 1.0 C B:VAL65 4.1 88.9 1.0 CD B:GLU195 4.3 92.5 1.0 CG B:ASP64 4.5 105.0 1.0 N B:VAL65 4.7 92.3 1.0 OH B:TYR233 4.8 105.0 1.0 OD2 B:ASP64 4.8 102.8 1.0 N B:ASP66 4.9 101.1 1.0 CA B:ASP66 4.9 104.5 1.0 CA B:VAL65 4.9 88.0 1.0

Calcium binding site 3 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca602 b:97.5 occ:1.00 O C:VAL65 3.1 95.0 1.0 OE2 C:GLU67 3.2 110.5 1.0 OD1 C:ASP64 3.4 108.0 1.0 OE1 C:GLU67 3.6 108.5 1.0 CD C:GLU67 3.7 111.6 1.0 OE2 C:GLU195 3.8 96.1 1.0 OE1 C:GLU195 3.9 89.7 1.0 C C:VAL65 4.1 88.9 1.0 CD C:GLU195 4.3 92.5 1.0 CG C:ASP64 4.5 105.0 1.0 N C:VAL65 4.7 92.3 1.0 OH C:TYR233 4.8 105.0 1.0 OD2 C:ASP64 4.8 102.8 1.0 N C:ASP66 4.9 101.1 1.0 CA C:ASP66 4.9 104.5 1.0 CA C:VAL65 4.9 88.0 1.0

Calcium binding site 4 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca602 b:97.5 occ:1.00 O D:VAL65 3.1 95.0 1.0 OE2 D:GLU67 3.2 110.5 1.0 OD1 D:ASP64 3.4 108.0 1.0 OE1 D:GLU67 3.6 108.5 1.0 CD D:GLU67 3.7 111.6 1.0 OE2 D:GLU195 3.8 96.1 1.0 OE1 D:GLU195 3.9 89.7 1.0 C D:VAL65 4.1 88.9 1.0 CD D:GLU195 4.3 92.5 1.0 CG D:ASP64 4.5 105.0 1.0 N D:VAL65 4.7 92.3 1.0 OH D:TYR233 4.8 105.0 1.0 OD2 D:ASP64 4.8 102.8 1.0 N D:ASP66 4.9 101.1 1.0 CA D:ASP66 4.9 104.5 1.0 CA D:VAL65 4.9 88.0 1.0

Calcium binding site 5 out of 5 in the Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State)


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Human Alpha 7 Nicotinic Acetylcholine Receptor in Complex with GAT107 and Calcium (Desensitized State) within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca602 b:97.5 occ:1.00 O E:VAL65 3.1 95.0 1.0 OE2 E:GLU67 3.2 110.5 1.0 OD1 E:ASP64 3.4 108.0 1.0 OE1 E:GLU67 3.6 108.5 1.0 CD E:GLU67 3.7 111.6 1.0 OE2 E:GLU195 3.8 96.1 1.0 OE1 E:GLU195 3.9 89.7 1.0 C E:VAL65 4.1 88.9 1.0 CD E:GLU195 4.3 92.5 1.0 CG E:ASP64 4.5 105.0 1.0 N E:VAL65 4.7 92.3 1.0 OH E:TYR233 4.8 105.0 1.0 OD2 E:ASP64 4.8 102.8 1.0 N E:ASP66 4.9 101.1 1.0 CA E:ASP66 4.9 104.5 1.0 CA E:VAL65 4.9 88.0 1.0

S.Liu, Y.Zheng, H.Chen, X.Li, Q.Yan, W.Mu, Y.Fu, H.Chen, H.Hou, L.Liu, C.Tian. Structural Basis For Allosteric Agonism of Human Alpha 7 Nicotinic Acetylcholine Receptors. Cell Discov V. 11 35 2025.
ISSN: ESSN 2056-5968
PubMed: 40195322
DOI: 10.1038/S41421-025-00788-Y