Calcium in PDB 9o51: Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State

The structure of Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State also contains other interesting chemical elements:

Potassium

(K)

2 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State (pdb code 9o51). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State, PDB code: 9o51:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca201 b:169.0 occ:1.00 O E:TYR100 2.4 157.3 1.0 N E:SER102 2.4 158.7 1.0 OE1 E:GLU105 2.6 164.6 1.0 C E:ILE101 3.0 157.7 1.0 OG E:SER102 3.0 151.0 1.0 CB E:SER102 3.0 150.7 1.0 CA E:ILE101 3.2 157.1 1.0 CA E:SER102 3.2 151.3 1.0 C E:TYR100 3.3 156.3 1.0 CD E:GLU105 3.7 160.9 1.0 N E:ILE101 3.7 157.6 1.0 NE2 E:GLN136 3.7 153.3 1.0 OD2 E:ASP96 3.8 164.3 1.0 O E:ILE101 3.9 156.2 1.0 OD1 E:ASN98 4.2 164.8 1.0 OE2 E:GLU105 4.2 157.7 1.0 OD1 E:ASP94 4.3 161.7 1.0 OD1 E:ASP96 4.4 160.5 1.0 CG E:ASP96 4.5 162.8 1.0 C E:SER102 4.5 146.4 1.0 CB E:ILE101 4.5 150.9 1.0 ND2 E:ASN98 4.6 156.8 1.0 CA E:TYR100 4.7 156.2 1.0 CG1 E:ILE101 4.7 144.2 1.0 CG E:GLU105 4.8 154.9 1.0 CD1 E:ILE101 4.8 144.1 1.0 CG E:ASN98 4.8 161.9 1.0 O E:SER102 4.9 148.9 1.0 CD E:GLN136 4.9 152.3 1.0 CB E:TYR100 5.0 158.6 1.0

Calcium binding site 2 out of 4 in the Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State within 5.0Å range: probe atom residue distance (Å) B Occ F:Ca201 b:167.2 occ:1.00 O F:TYR100 2.4 156.9 1.0 N F:SER102 2.4 157.8 1.0 OE1 F:GLU105 2.5 161.9 1.0 C F:ILE101 3.0 156.9 1.0 OG F:SER102 3.0 148.2 1.0 CB F:SER102 3.0 148.9 1.0 CA F:ILE101 3.2 156.8 1.0 CA F:SER102 3.2 150.6 1.0 C F:TYR100 3.3 156.2 1.0 CD F:GLU105 3.7 157.9 1.0 N F:ILE101 3.7 157.3 1.0 NE2 F:GLN136 3.7 154.5 1.0 OD2 F:ASP96 3.8 163.2 1.0 O F:ILE101 3.9 155.4 1.0 OD1 F:ASN98 4.2 164.6 1.0 OE2 F:GLU105 4.2 155.2 1.0 OD1 F:ASP94 4.4 162.2 1.0 OD1 F:ASP96 4.4 160.7 1.0 CG F:ASP96 4.5 162.9 1.0 CB F:ILE101 4.5 150.1 1.0 C F:SER102 4.5 145.5 1.0 ND2 F:ASN98 4.6 157.3 1.0 CA F:TYR100 4.7 156.2 1.0 CG1 F:ILE101 4.7 142.5 1.0 CD1 F:ILE101 4.7 141.3 1.0 CG F:GLU105 4.8 152.8 1.0 CG F:ASN98 4.8 162.5 1.0 O F:SER102 4.9 146.9 1.0 CD F:GLN136 4.9 154.3 1.0 CB F:TYR100 5.0 158.7 1.0

Calcium binding site 3 out of 4 in the Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State within 5.0Å range: probe atom residue distance (Å) B Occ G:Ca201 b:166.3 occ:1.00 O G:TYR100 2.4 156.6 1.0 N G:SER102 2.4 156.7 1.0 OE1 G:GLU105 2.5 162.4 1.0 C G:ILE101 3.0 156.4 1.0 OG G:SER102 3.0 148.1 1.0 CB G:SER102 3.0 148.4 1.0 CA G:ILE101 3.1 156.1 1.0 CA G:SER102 3.2 149.4 1.0 C G:TYR100 3.3 156.2 1.0 CD G:GLU105 3.6 157.4 1.0 N G:ILE101 3.7 156.9 1.0 NE2 G:GLN136 3.7 154.7 1.0 OD2 G:ASP96 3.8 161.9 1.0 O G:ILE101 3.9 156.1 1.0 OE2 G:GLU105 4.2 153.9 1.0 OD1 G:ASN98 4.2 164.7 1.0 OD1 G:ASP94 4.4 160.4 1.0 OD1 G:ASP96 4.4 158.9 1.0 CG G:ASP96 4.4 161.1 1.0 CB G:ILE101 4.5 150.1 1.0 C G:SER102 4.5 145.7 1.0 ND2 G:ASN98 4.7 157.0 1.0 CA G:TYR100 4.7 157.2 1.0 CG1 G:ILE101 4.7 141.9 1.0 CD1 G:ILE101 4.7 141.3 1.0 CG G:GLU105 4.7 151.6 1.0 CG G:ASN98 4.8 162.2 1.0 O G:SER102 4.9 147.9 1.0 CD G:GLN136 4.9 154.1 1.0 CB G:TYR100 5.0 159.2 1.0

Calcium binding site 4 out of 4 in the Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of the Human SK2-4 Chimera/Calmodulin Channel Complex in the CA2+ Free State within 5.0Å range: probe atom residue distance (Å) B Occ H:Ca201 b:168.3 occ:1.00 O H:TYR100 2.4 158.4 1.0 N H:SER102 2.4 158.6 1.0 OE1 H:GLU105 2.5 164.4 1.0 OG H:SER102 3.0 150.2 1.0 C H:ILE101 3.0 157.8 1.0 CB H:SER102 3.0 150.9 1.0 CA H:ILE101 3.2 157.6 1.0 CA H:SER102 3.2 151.4 1.0 C H:TYR100 3.3 157.7 1.0 CD H:GLU105 3.6 160.5 1.0 N H:ILE101 3.7 158.6 1.0 NE2 H:GLN136 3.7 154.3 1.0 OD2 H:ASP96 3.8 165.2 1.0 O H:ILE101 3.9 156.8 1.0 OE2 H:GLU105 4.2 157.4 1.0 OD1 H:ASN98 4.2 167.2 1.0 OD1 H:ASP94 4.4 163.4 1.0 OD1 H:ASP96 4.4 161.8 1.0 CG H:ASP96 4.4 164.3 1.0 CB H:ILE101 4.5 151.5 1.0 C H:SER102 4.5 147.1 1.0 ND2 H:ASN98 4.6 160.2 1.0 CA H:TYR100 4.7 158.1 1.0 CG1 H:ILE101 4.7 145.1 1.0 CG H:GLU105 4.7 155.0 1.0 CD1 H:ILE101 4.8 144.9 1.0 CG H:ASN98 4.8 164.8 1.0 O H:SER102 4.9 149.7 1.0 CD H:GLN136 4.9 154.2 1.0 CB H:TYR100 5.0 160.3 1.0

S.J.Cassell, W.Li, S.Krautwald, M.Khoshouei, Y.T.Lee, J.Hou, W.Guan, S.Peukert, W.A.Wilhelm, J.R.Whicher. Mechanism of SK2 Channel Gating and Its Modulation By the Bee Toxin Apamin and Small Molecules To Be Published.