Atomistry » Calcium » PDB 5jrc-5k8y » 5jyy
Atomistry »
  Calcium »
    PDB 5jrc-5k8y »
      5jyy »

Calcium in PDB 5jyy: Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses

Enzymatic activity of Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses

All present enzymatic activity of Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses:
3.2.1.18;

Protein crystallography data

The structure of Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses, PDB code: 5jyy was solved by L.Fu, Y.Wu, Y.Bi, S.Zhang, X.Lv, J.Qi, Y.Li, X.Lu, J.Yan, G.F.Gao, X.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.32 / 2.10
Space group I 4 3 2
Cell size a, b, c (Å), α, β, γ (°) 180.079, 180.079, 180.079, 90.00, 90.00, 90.00
R / Rfree (%) 15.1 / 17.2

Calcium Binding Sites:

The binding sites of Calcium atom in the Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses (pdb code 5jyy). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses, PDB code: 5jyy:

Calcium binding site 1 out of 1 in 5jyy

Go back to Calcium Binding Sites List in 5jyy
Calcium binding site 1 out of 1 in the Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca512

b:34.2
occ:1.00
 O A:GLY217 2.4 28.3 1.0
O A:ASP213 2.4 29.2 1.0
OD2 A:ASP244 2.4 27.9 1.0
O A:ASN266 2.4 24.7 1.0
O A:HOH711 2.5 23.8 1.0
O A:HOH744 2.6 26.4 1.0
CG A:ASP244 3.5 28.6 1.0
C A:ASN266 3.6 29.0 1.0
C A:GLY217 3.6 30.1 1.0
C A:ASP213 3.6 29.4 1.0
CA A:GLY267 3.9 27.2 1.0
O A:HOH661 4.0 20.9 1.0
CA A:ASN214 4.1 27.8 1.0
N A:GLY267 4.2 26.9 1.0
OD1 A:ASP244 4.3 25.2 1.0
N A:ASN214 4.3 27.2 1.0
C A:ASN214 4.4 29.5 1.0
CB A:ASP244 4.4 24.7 1.0
N A:SER218 4.5 31.2 1.0
N A:GLY217 4.5 28.3 1.0
CA A:SER218 4.5 27.7 1.0
CA A:GLY217 4.5 27.6 1.0
O A:ASN214 4.6 30.1 1.0
OG A:SER218 4.6 32.6 1.0
O A:ASN263 4.6 34.0 1.0
CA A:ASP213 4.7 28.1 1.0
N A:ASN266 4.7 26.5 1.0
CA A:ASN266 4.8 27.0 1.0
N A:ASP213 4.9 27.3 1.0
OD1 A:ASP213 4.9 28.8 1.0
CB A:ASP213 4.9 28.1 1.0
N A:TRP215 4.9 27.1 1.0
CG A:LYS212 5.0 30.3 1.0

Reference:

L.Fu, Y.Bi, Y.Wu, S.Zhang, J.Qi, Y.Li, X.Lu, Z.Zhang, X.Lv, J.Yan, G.F.Gao, X.Li. Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity Against Drug-Resistant Influenza Viruses J.Med.Chem. V. 59 6303 2016.
ISSN: ISSN 0022-2623
PubMed: 27341624
DOI: 10.1021/ACS.JMEDCHEM.6B00537
Page generated: Mon Jul 15 06:39:22 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy