Calcium in PDB 6cxy: Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11

The structure of Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11, PDB code: 6cxy was solved by Seattle Structural Genomics Center For Infectious Disease (Ssgcid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.09 / 2.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	122.680, 77.470, 110.940, 90.00, 92.91, 90.00
R / Rfree (%)	16.3 / 19.7

The binding sites of Calcium atom in the Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11 (pdb code 6cxy). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 3 binding sites of Calcium where determined in the Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11, PDB code: 6cxy:
Jump to Calcium binding site number: 1; 2; 3;

Calcium binding site 1 out of 3 in the Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca401 b:26.5 occ:1.00 O C:ASN104 2.3 25.1 1.0 OD2 C:ASP136 2.4 25.9 1.0 OD1 C:ASN102 2.4 24.7 1.0 OD2 C:ASP195 2.4 27.7 1.0 O C:ASN143 2.4 25.1 1.0 OD2 C:ASP134 2.4 21.3 1.0 OD1 C:ASP134 2.7 24.4 1.0 CG C:ASP134 2.9 25.1 1.0 CG C:ASP195 3.4 27.0 1.0 CG C:ASP136 3.4 26.6 1.0 C C:ASN104 3.5 25.9 1.0 CG C:ASN102 3.5 34.3 1.0 C C:ASN143 3.6 33.6 1.0 CB C:ASP136 3.8 20.6 1.0 CB C:ASP195 3.8 21.4 1.0 ND2 C:ASN102 4.1 27.3 1.0 N C:ASN104 4.2 26.1 1.0 CA C:ASN104 4.3 26.3 1.0 CB C:ASN143 4.4 22.5 1.0 OD1 C:ASP195 4.4 26.7 1.0 CA C:ASN143 4.4 34.4 1.0 CD1 C:LEU201 4.4 28.2 1.0 CB C:ASP134 4.4 23.6 1.0 CB C:ASN104 4.5 24.4 1.0 OD1 C:ASP136 4.5 26.9 1.0 N C:LYS105 4.5 26.3 1.0 N C:ALA144 4.6 21.2 1.0 CA C:ALA144 4.6 22.0 1.0 CB C:ASN102 4.7 26.5 1.0 CA C:LYS105 4.8 30.8 1.0 CA C:ASN102 4.8 28.6 1.0 CD C:PRO106 4.8 27.9 1.0 C C:LYS105 4.8 28.4 1.0 N C:ASP136 4.8 21.0 1.0 N C:PRO106 4.9 25.9 1.0 C C:ASN102 5.0 31.3 1.0 CA C:ASP136 5.0 24.6 1.0

Calcium binding site 2 out of 3 in the Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca402 b:27.7 occ:1.00 OD1 C:ASP100 2.3 25.7 1.0 OE2 C:GLU11 2.4 28.2 1.0 OD1 C:ASP136 2.4 26.9 1.0 OD1 C:ASP103 2.4 26.5 1.0 OE2 C:GLU69 2.4 28.3 1.0 O C:GLN101 2.5 25.0 1.0 OE1 C:GLU69 2.6 32.2 1.0 CD C:GLU69 2.8 31.6 1.0 CG C:ASP100 3.3 30.1 1.0 CG C:ASP136 3.4 26.6 1.0 CD C:GLU11 3.5 27.4 1.0 CG C:ASP103 3.5 28.1 1.0 C C:GLN101 3.6 28.2 1.0 OD2 C:ASP100 3.8 26.0 1.0 ND2 C:ASN104 3.8 25.9 1.0 N C:GLN101 3.9 26.0 1.0 OE1 C:GLU11 3.9 26.7 1.0 CA C:CA403 4.0 27.1 1.0 OD2 C:ASP103 4.1 29.6 1.0 CB C:ASP136 4.1 20.6 1.0 N C:ASP103 4.1 28.2 1.0 CA C:ASP136 4.3 24.6 1.0 CG C:GLU69 4.3 29.2 1.0 CA C:GLN101 4.4 26.3 1.0 OD2 C:ASP136 4.4 25.9 1.0 NE C:ARG68 4.5 28.2 1.0 CB C:ASP100 4.5 25.8 1.0 CA C:ASP100 4.6 27.0 1.0 CB C:ASP103 4.7 28.9 1.0 N C:ASN102 4.7 26.1 1.0 C C:ASP100 4.7 26.9 1.0 CG C:GLU11 4.8 24.2 1.0 CA C:ASP103 4.8 27.6 1.0 CB C:ARG68 4.8 27.5 1.0 CA C:ASN102 4.9 28.6 1.0 NH2 C:ARG68 5.0 31.1 1.0 CB C:GLN101 5.0 31.2 1.0

Calcium binding site 3 out of 3 in the Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca403 b:27.1 occ:1.00 OD2 C:ASP103 2.3 29.6 1.0 OD1 C:ASP67 2.3 24.8 1.0 OE1 C:GLU69 2.3 32.2 1.0 O C:HOH581 2.4 25.1 1.0 O C:HOH698 2.4 28.3 1.0 OE1 C:GLU11 2.4 26.7 1.0 CG C:ASP103 3.1 28.1 1.0 OD1 C:ASP103 3.2 26.5 1.0 CG C:ASP67 3.3 30.4 1.0 CD C:GLU11 3.3 27.4 1.0 CD C:GLU69 3.6 31.6 1.0 OE2 C:GLU11 3.6 28.2 1.0 CA C:CA402 4.0 27.7 1.0 OD2 C:ASP67 4.0 27.6 1.0 O C:HOH527 4.1 31.4 1.0 N C:ARG68 4.1 34.0 1.0 CA C:ASP67 4.2 29.0 1.0 ND2 C:ASN104 4.2 25.9 1.0 CB C:ASP67 4.2 23.1 1.0 N C:GLU69 4.2 28.2 1.0 CB C:GLU69 4.3 28.3 1.0 OD1 C:ASN12 4.3 27.6 1.0 CG C:GLU69 4.4 29.2 1.0 C C:ASP67 4.4 30.9 1.0 OE2 C:GLU69 4.4 28.3 1.0 ND2 C:ASN12 4.5 27.3 1.0 O C:HOH522 4.5 31.8 1.0 CB C:ASP103 4.6 28.9 1.0 CG C:GLU11 4.6 24.2 1.0 O H:HOH556 4.7 38.0 1.0 CG C:ASN12 4.8 30.3 1.0 CA C:GLU69 4.9 27.3 1.0 O C:HOH710 5.0 54.2 1.0

D.M.Dranow, J.N.Phan, A.Y.Maker, L.C.Schecterson, R.S.Mangio, B.M.Gumbiner, D.D.Lorimer, P.S.Horanyi, T.E.Edwards. Crystal Structure of Human E-Cadherin Bound By Mouse Monoclonal Antibody Fab Mab-1_19A11 To Be Published.