Calcium in PDB 6czq: A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model

The structure of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model, PDB code: 6czq was solved by Y.W.Nam, M.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.87 / 2.20
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	76.273, 66.726, 64.676, 90.00, 92.19, 90.00
R / Rfree (%)	19.8 / 24.9

The binding sites of Calcium atom in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model (pdb code 6czq). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model, PDB code: 6czq:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1001 b:64.3 occ:1.00 OD1 R:ASP22 2.3 67.6 1.0 O R:THR26 2.3 43.4 1.0 OD1 R:ASP20 2.4 59.6 1.0 OE2 R:GLU31 2.5 51.3 1.0 OE1 R:GLU31 2.6 51.0 1.0 CB R:ASP24 2.8 70.5 1.0 CD R:GLU31 2.9 49.8 1.0 CG R:ASP22 3.2 63.4 1.0 OD2 R:ASP22 3.4 66.1 1.0 OD2 R:ASP24 3.5 80.0 1.0 C R:THR26 3.5 49.1 1.0 CG R:ASP20 3.6 57.4 1.0 CG R:ASP24 3.7 77.1 1.0 N R:ASP24 3.9 72.5 1.0 CA R:ASP24 4.0 72.7 1.0 OG1 R:THR26 4.2 65.5 1.0 OD2 R:ASP20 4.3 60.1 1.0 N R:THR26 4.3 53.7 1.0 CG R:GLU31 4.4 45.8 1.0 CA R:ASP20 4.4 51.0 1.0 N R:ILE27 4.4 42.9 1.0 N R:ASP22 4.5 67.1 1.0 CA R:ILE27 4.5 45.6 1.0 CA R:THR26 4.5 56.6 1.0 CB R:ASP22 4.5 61.5 1.0 CB R:ASP20 4.5 55.3 1.0 C R:ASP20 4.6 58.0 1.0 N R:LYS21 4.7 60.0 1.0 N R:THR28 4.7 41.2 1.0 CG2 R:THR28 4.7 38.2 1.0 C R:ASP24 4.8 61.5 1.0 OD1 R:ASP24 4.8 83.8 1.0 CA R:ASP22 4.9 66.7 1.0 N R:GLY25 4.9 58.6 1.0 CB R:THR26 5.0 59.5 1.0

Calcium binding site 2 out of 2 in the A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of A V-to-F Substitution in SK2 Channels Causes CA2+ Hypersensitivity and Improves Locomotion in A C. Elegans Als Model within 5.0Å range: probe atom residue distance (Å) B Occ R:Ca1002 b:55.7 occ:1.00 O R:THR62 2.4 53.1 1.0 OD1 R:ASP56 2.5 48.2 1.0 OE2 R:GLU67 2.5 53.0 1.0 O R:HOH1144 2.6 62.8 1.0 OD1 R:ASN60 2.6 58.1 1.0 OD1 R:ASP58 2.8 71.1 1.0 OE1 R:GLU67 3.0 68.0 1.0 CD R:GLU67 3.1 62.2 1.0 O R:HOH1149 3.2 49.7 1.0 OD2 R:ASP58 3.2 75.4 1.0 CG R:ASN60 3.3 54.3 1.0 CG R:ASP58 3.4 69.9 1.0 ND2 R:ASN60 3.5 60.4 1.0 CG R:ASP56 3.5 67.3 1.0 C R:THR62 3.5 51.0 1.0 OD2 R:ASP64 3.7 82.7 1.0 OD2 R:ASP56 4.0 59.3 1.0 N R:ASP64 4.1 49.5 1.0 CG R:ASP64 4.2 76.1 1.0 OG1 R:THR62 4.2 46.8 1.0 CA R:ILE63 4.3 49.0 1.0 N R:ILE63 4.3 47.8 1.0 N R:THR62 4.4 55.5 1.0 CA R:THR62 4.5 50.2 1.0 CB R:ASP56 4.5 66.4 1.0 C R:ILE63 4.5 51.2 1.0 CG R:GLU67 4.5 52.2 1.0 CA R:ASP56 4.6 67.0 1.0 CB R:ASN60 4.7 56.1 1.0 N R:ASN60 4.7 57.8 1.0 CB R:ASP64 4.7 66.0 1.0 N R:ASP58 4.8 69.2 1.0 CB R:ASP58 4.8 68.8 1.0 OD1 R:ASP64 4.9 78.3 1.0 N R:ALA57 4.9 64.2 1.0

Y.W.Nam, S.N.Baskoylu, D.Gazgalis, R.Orfali, M.Cui, A.C.Hart, M.Zhang. A V-to-F Substitution in SK2 Channels Causes CA2+Hypersensitivity and Improves Locomotion in A C. Elegans Als Model. Sci Rep V. 8 10749 2018.
ISSN: ESSN 2045-2322
PubMed: 30013223
DOI: 10.1038/S41598-018-28783-2