Calcium in PDB 6e2g: Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin

The binding sites of Calcium atom in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin (pdb code 6e2g). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 6 binding sites of Calcium where determined in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin, PDB code: 6e2g:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6;

Calcium binding site 1 out of 6 in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca801 b:0.9 occ:1.00 OD1 D:ASP541 2.4 97.9 1.0 OD2 C:ASP541 2.4 0.8 1.0 OD1 A:ASP541 2.4 0.5 1.0 OD2 B:ASP541 2.4 0.2 1.0 OD1 C:ASP541 2.5 0.8 1.0 OD2 A:ASP541 2.5 0.5 1.0 OD1 B:ASP541 2.5 0.2 1.0 OD2 D:ASP541 2.5 97.9 1.0 CG D:ASP541 2.8 97.9 1.0 CG A:ASP541 2.8 0.5 1.0 CG B:ASP541 2.8 0.2 1.0 CG C:ASP541 2.8 0.8 1.0 CA A:CA802 4.1 81.0 1.0 CB D:ASP541 4.2 97.9 1.0 CB B:ASP541 4.2 0.2 1.0 CB A:ASP541 4.2 0.5 1.0 CB C:ASP541 4.2 0.8 1.0 CA D:ASP541 5.0 97.9 1.0

Calcium binding site 2 out of 6 in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca802 b:81.0 occ:1.00 OD1 A:ASP541 3.5 0.5 1.0 OD1 B:ASP541 3.7 0.2 1.0 OD1 D:ASP541 3.7 97.9 1.0 OD1 C:ASP541 3.9 0.8 1.0 CA A:CA801 4.1 0.9 1.0 O D:ILE539 4.7 90.7 1.0 O A:ILE539 4.7 95.1 1.0 CG A:ASP541 4.8 0.5 1.0 CG B:ASP541 4.8 0.2 1.0 CG D:ASP541 4.9 97.9 1.0

Calcium binding site 3 out of 6 in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca401 b:0.1 occ:1.00 O E:THR26 2.5 0.5 1.0 OD1 E:ASP20 2.5 0.1 1.0 OE1 E:GLU31 2.6 0.0 1.0 CG E:ASP20 2.8 0.1 1.0 CG1 E:ILE27 2.9 0.7 1.0 CA E:ASP20 3.0 0.1 1.0 CB E:ASP20 3.1 0.1 1.0 CA E:ILE27 3.3 0.7 1.0 C E:THR26 3.5 0.5 1.0 CB E:ILE27 3.5 0.7 1.0 OD2 E:ASP20 3.6 0.1 1.0 CD E:GLU31 3.7 0.0 1.0 N E:ILE27 3.8 0.7 1.0 N E:ASP20 3.9 0.1 1.0 CB E:GLU31 3.9 0.0 1.0 CG2 E:ILE27 4.0 0.7 1.0 C E:ASP20 4.0 0.1 1.0 CD1 E:ILE27 4.1 0.7 1.0 N E:LYS21 4.2 0.1 1.0 O E:PHE19 4.2 0.8 1.0 C E:PHE19 4.4 0.8 1.0 CG E:GLU31 4.4 0.0 1.0 OD1 E:ASP24 4.5 0.8 1.0 C E:ILE27 4.6 0.7 1.0 OE2 E:GLU31 4.7 0.0 1.0 CD2 E:PHE19 4.7 0.8 1.0 N E:THR28 4.8 0.7 1.0 CA E:THR26 4.8 0.5 1.0 CE1 E:PHE16 4.9 0.7 1.0 OD1 E:ASP22 4.9 1.0 1.0 CZ E:PHE16 5.0 0.7 1.0

Calcium binding site 4 out of 6 in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca402 b:0.4 occ:1.00 OD1 E:ASN60 2.6 0.2 1.0 ND2 E:ASN60 2.6 0.2 1.0 O E:THR62 2.7 0.5 1.0 OE1 E:GLU67 2.7 0.4 1.0 OD1 E:ASP58 2.8 0.4 1.0 CG E:ASN60 3.0 0.2 1.0 OD2 E:ASP58 3.3 0.4 1.0 CD E:GLU67 3.4 0.4 1.0 OD1 E:ASP56 3.4 0.3 1.0 CG E:ASP58 3.5 0.4 1.0 C E:THR62 3.5 0.5 1.0 OE2 E:GLU67 3.6 0.4 1.0 OG1 E:THR62 3.7 0.5 1.0 OD1 E:ASP64 3.7 0.9 1.0 N E:ASP64 3.9 0.9 1.0 CG E:ASP64 4.1 0.9 1.0 N E:ILE63 4.2 0.6 1.0 CA E:ILE63 4.2 0.6 1.0 CA E:THR62 4.4 0.5 1.0 CG E:ASP56 4.4 0.3 1.0 CB E:ASN60 4.4 0.2 1.0 C E:ILE63 4.5 0.6 1.0 N E:THR62 4.6 0.5 1.0 CB E:THR62 4.6 0.5 1.0 OD2 E:ASP64 4.6 0.9 1.0 CG E:GLU67 4.6 0.4 1.0 CB E:ASP64 4.7 0.9 1.0 OD2 E:ASP56 4.8 0.3 1.0 CA E:ASP64 4.9 0.9 1.0 CB E:ASP58 5.0 0.4 1.0

Calcium binding site 5 out of 6 in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca403 b:0.2 occ:1.00 OE2 E:GLU104 2.5 0.9 1.0 O E:TYR99 2.5 0.8 1.0 OD1 E:ASN97 2.5 1.0 1.0 ND2 E:ASN97 2.7 1.0 1.0 OE1 E:GLU104 2.7 0.9 1.0 OD1 E:ASP95 2.8 0.0 1.0 CD E:GLU104 2.9 0.9 1.0 CG E:ASN97 2.9 1.0 1.0 OD2 E:ASP95 3.1 0.0 1.0 CG E:ASP95 3.3 0.0 1.0 OD1 E:ASP93 3.5 0.2 1.0 C E:TYR99 3.7 0.8 1.0 CB E:TYR99 4.2 0.8 1.0 CG E:GLU104 4.3 0.9 1.0 CA E:TYR99 4.3 0.8 1.0 CB E:ASN97 4.4 1.0 1.0 CG E:ASP93 4.5 0.2 1.0 N E:TYR99 4.5 0.8 1.0 OD2 E:ASP93 4.7 0.2 1.0 N E:ILE100 4.8 0.4 1.0 CB E:ASP95 4.8 0.0 1.0 OG E:SER101 4.9 0.3 1.0 N E:ASN97 5.0 1.0 1.0

Calcium binding site 6 out of 6 in the Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Cryo-Em Structure of Rat TRPV6 in Complex with Calmodulin within 5.0Å range: probe atom residue distance (Å) B Occ E:Ca404 b:0.4 occ:1.00 OD1 E:ASP131 2.5 0.6 1.0 OD1 E:ASP133 2.5 0.7 1.0 OE1 E:GLU140 2.6 0.6 1.0 O E:GLN135 2.6 0.0 1.0 OE2 E:GLU140 2.9 0.6 1.0 OD1 E:ASP129 3.0 0.2 1.0 CD E:GLU140 3.1 0.6 1.0 OD2 E:ASP133 3.1 0.7 1.0 OD1 E:ASN137 3.2 0.1 1.0 CG E:ASP133 3.2 0.7 1.0 CG E:ASP131 3.3 0.6 1.0 OD2 E:ASP131 3.3 0.6 1.0 C E:GLN135 3.7 0.0 1.0 CG E:ASP129 4.0 0.2 1.0 CG E:ASN137 4.1 0.1 1.0 N E:ASN137 4.3 0.1 1.0 N E:VAL136 4.5 0.4 1.0 OD2 E:ASP129 4.6 0.2 1.0 CG E:GLU140 4.6 0.6 1.0 CA E:VAL136 4.6 0.4 1.0 CB E:ASP133 4.6 0.7 1.0 N E:GLN135 4.7 0.0 1.0 CA E:GLN135 4.7 0.0 1.0 N E:ASP133 4.7 0.7 1.0 CB E:ASP131 4.8 0.6 1.0 NH2 C:ARG642 4.8 0.6 1.0 C E:VAL136 4.8 0.4 1.0 ND2 E:ASN137 4.9 0.1 1.0 CB E:ASN137 4.9 0.1 1.0 N E:ASP131 4.9 0.6 1.0 N E:GLY132 4.9 0.3 1.0 CB E:GLN135 5.0 0.0 1.0

A.K.Singh, L.L.Mcgoldrick, E.C.Twomey, A.I.Sobolevsky. Mechanism of Calmodulin Inactivation of the Calcium-Selective Trp Channel TRPV6. Sci Adv V. 4 U6088 2018.
ISSN: ESSN 2375-2548
PubMed: 30116787
DOI: 10.1126/SCIADV.AAU6088