Calcium in PDB 7bvc: Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol

Enzymatic activity of Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol

All present enzymatic activity of Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol:
2.4.2.34;

Calcium Binding Sites:

The binding sites of Calcium atom in the Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol (pdb code 7bvc). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 2 binding sites of Calcium where determined in the Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol, PDB code: 7bvc:
Jump to Calcium binding site number: 1; 2;

Calcium binding site 1 out of 2 in 7bvc

Go back to Calcium Binding Sites List in 7bvc
Calcium binding site 1 out of 2 in the Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ca1103

b:80.1
occ:1.00
O A:ASN933 2.5 80.3 1.0
O A:GLN938 2.8 79.5 1.0
OD1 A:ASP931 3.0 80.5 1.0
OD2 A:ASP931 3.5 80.5 1.0
CG A:ASP931 3.6 80.5 1.0
O A:GLU831 3.6 87.7 1.0
C A:ASN933 3.7 80.3 1.0
C A:GLN938 4.0 79.5 1.0
O A:SER935 4.1 81.2 1.0
CA A:LEU934 4.5 79.4 1.0
OG A:SER828 4.5 79.3 1.0
N A:LEU934 4.5 79.4 1.0
C A:GLU831 4.7 87.7 1.0
O A:SER828 4.7 79.3 1.0
CA A:ASN933 4.7 80.3 1.0
C A:LEU934 4.8 79.4 1.0
N A:ASN933 4.8 80.3 1.0
CA A:TRP939 4.8 74.6 1.0
CB A:TRP939 4.8 74.6 1.0
N A:TRP939 4.8 74.6 1.0
O A:ASP931 4.9 80.5 1.0
CB A:GLN938 4.9 79.5 1.0
N A:SER935 4.9 81.2 1.0
CA A:GLN938 4.9 79.5 1.0

Calcium binding site 2 out of 2 in 7bvc

Go back to Calcium Binding Sites List in 7bvc
Calcium binding site 2 out of 2 in the Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Cryo-Em Structure of Mycobacterium Smegmatis Arabinosyltransferase Emba-Embb-ACPM2 in Complex with Ethambutol within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ca1205

b:69.9
occ:1.00
O B:SER938 2.5 75.4 1.0
O B:ASP943 2.7 77.9 1.0
OD2 B:ASP936 2.7 75.7 1.0
CG B:ASP936 3.5 75.7 1.0
OD1 B:ASP936 3.5 75.7 1.0
O B:SER940 3.6 76.5 1.0
C B:SER938 3.7 75.4 1.0
C B:ASP943 3.9 77.9 1.0
OE1 B:GLN834 4.1 82.6 1.0
O B:GLN835 4.3 79.3 1.0
CG2 B:THR828 4.4 74.5 1.0
CA B:LEU939 4.5 72.7 1.0
N B:LEU939 4.6 72.7 1.0
CA B:SER938 4.7 75.4 1.0
C B:LEU939 4.7 72.7 1.0
C B:SER940 4.7 76.5 1.0
CA B:TRP944 4.7 68.8 1.0
N B:SER938 4.8 75.4 1.0
N B:TRP944 4.8 68.8 1.0
CB B:ASP943 4.8 77.9 1.0
N B:SER940 4.8 76.5 1.0
CA B:ASP943 4.9 77.9 1.0
CB B:ASP936 4.9 75.7 1.0
CB B:SER938 4.9 75.4 1.0

Reference:

L.Zhang, Y.Zhao, Y.Gao, L.Wu, R.Gao, Q.Zhang, Y.Wang, C.Wu, F.Wu, S.S.Gurcha, N.Veerapen, S.M.Batt, W.Zhao, L.Qin, X.Yang, M.Wang, Y.Zhu, B.Zhang, L.Bi, X.Zhang, H.Yang, L.W.Guddat, W.Xu, Q.Wang, J.Li, G.S.Besra, Z.Rao. Structures of Cell Wall Arabinosyltransferases with the Anti-Tuberculosis Drug Ethambutol Science 2020.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.ABA9102
Page generated: Sat Dec 12 08:03:10 2020

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