Calcium in PDB 7pxh: Emodepside-Bound Drosophila Slo Channel

The structure of Emodepside-Bound Drosophila Slo Channel also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Potassium	(K)	6 atoms

The binding sites of Calcium atom in the Emodepside-Bound Drosophila Slo Channel (pdb code 7pxh). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 8 binding sites of Calcium where determined in the Emodepside-Bound Drosophila Slo Channel, PDB code: 7pxh:
Jump to Calcium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Calcium binding site 1 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1201 b:59.9 occ:1.00 O A:ASP980 2.5 64.0 1.0 OD1 A:ASP985 2.5 72.0 1.0 OD2 A:ASP985 2.5 72.0 1.0 OD1 A:ASP983 2.5 71.5 1.0 O A:GLN977 2.5 58.5 1.0 OD1 C:ASN463 2.6 52.7 1.0 CG A:ASP985 2.9 72.0 1.0 CG A:ASP983 3.3 71.5 1.0 CG C:ASN463 3.5 52.7 1.0 OD2 A:ASP983 3.5 71.5 1.0 C A:ASP980 3.6 64.0 1.0 C A:GLN977 3.7 58.5 1.0 O A:ASP983 3.7 71.5 1.0 ND2 C:ASN463 3.7 52.7 1.0 CA A:GLN977 4.3 58.5 1.0 N A:GLN981 4.3 67.6 1.0 CA A:GLN981 4.4 67.6 1.0 CB A:ASP985 4.4 72.0 1.0 C A:ASP983 4.4 71.5 1.0 CA A:ASP980 4.5 64.0 1.0 O A:GLN981 4.5 67.6 1.0 C A:GLN981 4.6 67.6 1.0 CB A:ASP983 4.6 71.5 1.0 N A:ASP980 4.6 64.0 1.0 CB A:GLN977 4.7 58.5 1.0 CB A:ASP980 4.7 64.0 1.0 N A:ASP983 4.7 71.5 1.0 N A:PHE978 4.8 54.9 1.0 CA A:ASP983 4.8 71.5 1.0 CB C:ASN463 4.9 52.7 1.0

Calcium binding site 2 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1202 b:57.5 occ:1.00 O A:GLY548 2.4 56.7 1.0 OD2 A:ASP381 2.4 64.7 1.0 O A:GLN616 2.5 61.7 1.0 O A:ARG528 2.5 61.0 1.0 OE2 A:GLU550 2.5 59.6 1.0 CD A:GLU550 2.8 59.6 1.0 OE1 A:GLU550 2.9 59.6 1.0 CG A:ASP381 3.3 64.7 1.0 C A:GLY548 3.5 56.7 1.0 C A:GLN616 3.6 61.7 1.0 C A:ARG528 3.7 61.0 1.0 CG A:GLU550 3.8 59.6 1.0 CB A:ASP381 4.0 64.7 1.0 OD1 A:ASP381 4.0 64.7 1.0 OH A:TYR552 4.2 61.6 1.0 CA A:GLY548 4.2 56.7 1.0 N A:ARG528 4.2 61.0 1.0 CA A:GLN616 4.3 61.7 1.0 N A:MET549 4.5 59.5 1.0 CA A:ARG528 4.5 61.0 1.0 N A:SER529 4.6 70.2 1.0 CB A:GLU550 4.6 59.6 1.0 CA A:SER529 4.7 70.2 1.0 N A:SER617 4.7 64.6 1.0 CA A:MET549 4.7 59.5 1.0 OE1 A:GLN616 4.8 61.7 1.0 N A:GLU550 4.9 59.6 1.0 C A:MET549 4.9 59.5 1.0 O A:ALA615 4.9 59.1 1.0 CA A:SER617 4.9 64.6 1.0

Calcium binding site 3 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1201 b:60.2 occ:1.00 O B:ASP980 2.5 64.4 1.0 OD1 B:ASP985 2.5 71.8 1.0 OD2 B:ASP985 2.5 71.8 1.0 OD1 B:ASP983 2.5 71.2 1.0 OD1 D:ASN463 2.5 53.2 1.0 O B:GLN977 2.5 58.6 1.0 CG B:ASP985 2.9 71.8 1.0 CG B:ASP983 3.3 71.2 1.0 CG D:ASN463 3.5 53.2 1.0 OD2 B:ASP983 3.5 71.2 1.0 C B:ASP980 3.6 64.4 1.0 ND2 D:ASN463 3.7 53.2 1.0 C B:GLN977 3.7 58.6 1.0 O B:ASP983 3.7 71.2 1.0 CA B:GLN977 4.3 58.6 1.0 N B:GLN981 4.3 68.6 1.0 CA B:GLN981 4.4 68.6 1.0 CB B:ASP985 4.4 71.8 1.0 C B:ASP983 4.4 71.2 1.0 CA B:ASP980 4.5 64.4 1.0 O B:GLN981 4.5 68.6 1.0 C B:GLN981 4.6 68.6 1.0 CB B:ASP983 4.6 71.2 1.0 N B:ASP980 4.6 64.4 1.0 CB B:GLN977 4.7 58.6 1.0 CB B:ASP980 4.7 64.4 1.0 N B:ASP983 4.7 71.2 1.0 N B:PHE978 4.8 55.2 1.0 O D:ASN463 4.8 53.2 1.0 CA B:ASP983 4.8 71.2 1.0 CB D:ASN463 4.9 53.2 1.0

Calcium binding site 4 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1202 b:56.4 occ:1.00 O B:GLY548 2.4 57.1 1.0 OD2 B:ASP381 2.4 64.4 1.0 O B:GLN616 2.5 62.0 1.0 O B:ARG528 2.5 60.6 1.0 OE2 B:GLU550 2.5 60.0 1.0 CD B:GLU550 2.8 60.0 1.0 OE1 B:GLU550 2.9 60.0 1.0 CG B:ASP381 3.3 64.4 1.0 C B:GLY548 3.5 57.1 1.0 C B:GLN616 3.6 62.0 1.0 C B:ARG528 3.7 60.6 1.0 CG B:GLU550 3.8 60.0 1.0 CB B:ASP381 4.0 64.4 1.0 OD1 B:ASP381 4.0 64.4 1.0 OH B:TYR552 4.2 62.0 1.0 CA B:GLY548 4.2 57.1 1.0 N B:ARG528 4.2 60.6 1.0 CA B:GLN616 4.3 62.0 1.0 CA B:ARG528 4.5 60.6 1.0 N B:MET549 4.5 59.7 1.0 N B:SER529 4.6 70.5 1.0 CB B:GLU550 4.6 60.0 1.0 CA B:SER529 4.7 70.5 1.0 N B:SER617 4.7 65.1 1.0 CA B:MET549 4.7 59.7 1.0 OE1 B:GLN616 4.8 62.0 1.0 N B:GLU550 4.9 60.0 1.0 C B:MET549 4.9 59.7 1.0 O B:ALA615 4.9 59.6 1.0 CA B:SER617 4.9 65.1 1.0

Calcium binding site 5 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 5 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1201 b:62.6 occ:1.00 O C:GLN977 2.5 58.4 1.0 OD1 C:ASP983 2.5 73.3 1.0 O C:ASP980 2.6 64.2 1.0 OD1 C:ASP985 2.6 72.3 1.0 OD2 C:ASP983 2.9 73.3 1.0 CG C:ASP983 3.0 73.3 1.0 OD2 C:ASP985 3.0 72.3 1.0 OD1 B:ASN463 3.2 52.8 1.0 CG C:ASP985 3.2 72.3 1.0 C C:ASP980 3.4 64.2 1.0 C C:GLN977 3.5 58.4 1.0 CA C:GLN977 4.0 58.4 1.0 CB C:ASP980 4.0 64.2 1.0 CA C:ASP980 4.0 64.2 1.0 O C:ASP983 4.1 73.3 1.0 CG B:ASN463 4.1 52.8 1.0 N C:ASP980 4.1 64.2 1.0 N C:GLN981 4.3 67.8 1.0 ND2 B:ASN463 4.3 52.8 1.0 CB C:ASP983 4.4 73.3 1.0 C C:ASP983 4.6 73.3 1.0 CB C:GLN977 4.6 58.4 1.0 CA C:GLN981 4.6 67.8 1.0 N C:PHE978 4.6 55.2 1.0 CB C:ASP985 4.7 72.3 1.0 O C:VAL976 4.8 59.1 1.0 N C:ASP983 4.8 73.3 1.0 C C:GLN981 4.8 67.8 1.0 CA C:ASP983 4.8 73.3 1.0 O C:GLN981 4.9 67.8 1.0

Calcium binding site 6 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 6 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1202 b:56.3 occ:1.00 O C:GLN616 2.5 59.7 1.0 O C:ARG528 2.5 61.9 1.0 OE2 C:GLU550 2.6 58.8 1.0 OE1 C:GLU550 2.6 58.8 1.0 O C:GLY548 2.6 55.7 1.0 OD2 C:ASP381 2.7 62.3 1.0 CD C:GLU550 2.9 58.8 1.0 C C:GLY548 3.6 55.7 1.0 CG C:ASP381 3.6 62.3 1.0 C C:GLN616 3.6 59.7 1.0 C C:ARG528 3.6 61.9 1.0 CA C:GLY548 4.1 55.7 1.0 N C:ARG528 4.2 61.9 1.0 CB C:ASP381 4.2 62.3 1.0 CA C:GLN616 4.2 59.7 1.0 OE1 C:GLN616 4.4 59.7 1.0 CG C:GLU550 4.4 58.8 1.0 CA C:ARG528 4.5 61.9 1.0 OD1 C:ASP381 4.5 62.3 1.0 N C:SER529 4.5 71.8 1.0 CA C:SER529 4.6 71.8 1.0 OH C:TYR552 4.6 59.9 1.0 N C:MET549 4.7 59.1 1.0 N C:SER617 4.7 63.2 1.0 O C:ALA615 4.9 58.2 1.0 CB C:GLN616 5.0 59.7 1.0 CA C:SER617 5.0 63.2 1.0

Calcium binding site 7 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 7 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:66.5 occ:1.00 O D:GLN977 2.5 59.3 1.0 OD1 D:ASP983 2.5 74.0 1.0 O D:ASP980 2.6 65.3 1.0 OD1 D:ASP985 2.6 73.1 1.0 OD2 D:ASP983 2.9 74.0 1.0 CG D:ASP983 3.0 74.0 1.0 OD2 D:ASP985 3.0 73.1 1.0 CG D:ASP985 3.2 73.1 1.0 OD1 A:ASN463 3.4 53.1 1.0 C D:ASP980 3.4 65.3 1.0 C D:GLN977 3.5 59.3 1.0 CA D:GLN977 4.0 59.3 1.0 CB D:ASP980 4.0 65.3 1.0 CA D:ASP980 4.0 65.3 1.0 O D:ASP983 4.1 74.0 1.0 N D:ASP980 4.1 65.3 1.0 CG A:ASN463 4.3 53.1 1.0 N D:GLN981 4.3 69.4 1.0 CB D:ASP983 4.4 74.0 1.0 ND2 A:ASN463 4.4 53.1 1.0 C D:ASP983 4.6 74.0 1.0 CB D:GLN977 4.6 59.3 1.0 CA D:GLN981 4.6 69.4 1.0 N D:PHE978 4.6 55.9 1.0 CB D:ASP985 4.7 73.1 1.0 O D:VAL976 4.8 59.4 1.0 N D:ASP983 4.8 74.0 1.0 C D:GLN981 4.8 69.4 1.0 CA D:ASP983 4.8 74.0 1.0 O D:GLN981 4.9 69.4 1.0

Calcium binding site 8 out of 8 in the Emodepside-Bound Drosophila Slo Channel


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 8 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1202 b:56.1 occ:1.00 O D:GLN616 2.5 60.2 1.0 O D:ARG528 2.5 62.3 1.0 OE2 D:GLU550 2.6 59.6 1.0 OE1 D:GLU550 2.6 59.6 1.0 O D:GLY548 2.6 56.5 1.0 OD2 D:ASP381 2.7 63.3 1.0 CD D:GLU550 2.9 59.6 1.0 C D:GLY548 3.6 56.5 1.0 CG D:ASP381 3.6 63.3 1.0 C D:GLN616 3.6 60.2 1.0 C D:ARG528 3.6 62.3 1.0 CA D:GLY548 4.1 56.5 1.0 N D:ARG528 4.2 62.3 1.0 CB D:ASP381 4.2 63.3 1.0 CA D:GLN616 4.2 60.2 1.0 OE1 D:GLN616 4.4 60.2 1.0 CG D:GLU550 4.4 59.6 1.0 CA D:ARG528 4.5 62.3 1.0 OD1 D:ASP381 4.5 63.3 1.0 N D:SER529 4.5 72.0 1.0 CA D:SER529 4.6 72.0 1.0 OH D:TYR552 4.6 60.7 1.0 N D:MET549 4.7 60.1 1.0 N D:SER617 4.7 64.0 1.0 O D:ALA615 4.9 58.9 1.0 CB D:GLN616 5.0 60.2 1.0 CA D:SER617 5.0 64.0 1.0

T.Raisch, A.Brockmann, U.Ebbinghaus-Kintscher, J.Freigang, O.Gutbrod, J.Kubicek, B.Maertens, O.Hofnagel, S.Raunser. Small Molecule Modulation of the Drosophila Slo Channel Elucidated By Cryo-Em To Be Published.
DOI: 10.1038/S41467-021-27435-W