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Calcium in PDB 6szj: RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE.
Enzymatic activity of RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE.
All present enzymatic activity of RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE.:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE., PDB code: 6szj
was solved by
M.A.Convery,
A.K.Charnley,
L.Shewchuk,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.53 |
| Space group | P 32 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 132.182, 132.182, 107.088, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 18.9 / 24.1 |
Calcium Binding Sites:
The binding sites of Calcium atom in the RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE.
(pdb code 6szj). This binding sites where shown within
5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE., PDB code: 6szj:
In total only one binding site of Calcium was determined in the RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE., PDB code: 6szj:
Calcium binding site 1 out of 1 in 6szj
Go back to
Calcium Binding Sites List in 6szj
Calcium binding site 1 out
of 1 in the RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Calcium with other atoms in the Ca binding
site number 1 of RIP2 Kinase Catalytic Domain Complex with 5AMINO1TERTBUTYL3(3METHOXYPHENYL)1H PYRAZOLE4CARBOXAMIDE. within 5.0Å range:
|
Reference:
C.D.Haffner,
A.K.Charnley,
C.J.Aquino,
L.Casillas,
M.A.Convery,
J.A.Cox,
M.A.Elban,
N.C.Goodwin,
P.J.Gough,
P.A.Haile,
T.V.Hughes,
B.Knapp-Reed,
C.Kreatsoulas,
A.S.Lakdawala,
H.Li,
Y.Lian,
D.Lipshutz,
J.F.Mehlmann,
M.Ouellette,
J.Romano,
L.Shewchuk,
A.Shu,
B.J.Votta,
H.Zhou,
J.Bertin,
R.W.Marquis.
Discovery of Pyrazolocarboxamides As Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors. Acs Med.Chem.Lett. V. 10 1518 2019.
ISSN: ISSN 1948-5875
PubMed: 31749904
DOI: 10.1021/ACSMEDCHEMLETT.9B00141
Page generated: Wed Jul 9 18:01:25 2025
ISSN: ISSN 1948-5875
PubMed: 31749904
DOI: 10.1021/ACSMEDCHEMLETT.9B00141
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