Calcium in PDB 7k4f: Cryo-Em Structure of Human TRPV6 in Complex with (4- Phenylcyclohexyl)Piperazine Inhibitor 31

The structure of Cryo-Em Structure of Human TRPV6 in Complex with (4- Phenylcyclohexyl)Piperazine Inhibitor 31 also contains other interesting chemical elements:

Fluorine

(F)

15 atoms

The binding sites of Calcium atom in the Cryo-Em Structure of Human TRPV6 in Complex with (4- Phenylcyclohexyl)Piperazine Inhibitor 31 (pdb code 7k4f). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total only one binding site of Calcium was determined in the Cryo-Em Structure of Human TRPV6 in Complex with (4- Phenylcyclohexyl)Piperazine Inhibitor 31, PDB code: 7k4f:

Calcium binding site 1 out of 1 in the Cryo-Em Structure of Human TRPV6 in Complex with (4- Phenylcyclohexyl)Piperazine Inhibitor 31


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of Cryo-Em Structure of Human TRPV6 in Complex with (4- Phenylcyclohexyl)Piperazine Inhibitor 31 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca703 b:65.5 occ:1.00 OD1 A:ASP542 2.5 0.6 1.0 OD1 D:ASP542 2.5 0.0 1.0 OD1 B:ASP542 2.6 0.1 1.0 OD1 C:ASP542 2.6 0.4 1.0 CG D:ASP542 3.6 0.0 1.0 CG A:ASP542 3.7 0.6 1.0 CG B:ASP542 3.8 0.1 1.0 CG C:ASP542 3.8 0.4 1.0 CB D:ASP542 4.1 0.0 1.0 CB A:ASP542 4.3 0.6 1.0 CA D:ASP542 4.3 0.0 1.0 CB B:ASP542 4.4 0.1 1.0 CB C:ASP542 4.4 0.4 1.0 CA A:ASP542 4.5 0.6 1.0 CA B:ASP542 4.6 0.1 1.0 CA C:ASP542 4.6 0.4 1.0 OD2 A:ASP542 4.7 0.6 1.0 OD2 D:ASP542 4.7 0.0 1.0 OD2 B:ASP542 4.7 0.1 1.0 OD2 C:ASP542 4.8 0.4 1.0

R.Bhardwaj, S.Lindinger, A.Neuberger, K.D.Nadezhdin, A.K.Singh, M.R.Cunha, I.Derler, G.Gyimesi, J.L.Reymond, M.A.Hediger, C.Romanin, A.I.Sobolevsky. Inactivation-Mimicking Block of the Epithelial Calcium Channel TRPV6. Sci Adv V. 6 2020.
ISSN: ESSN 2375-2548
PubMed: 33246965
DOI: 10.1126/SCIADV.ABE1508