Calcium in PDB 8e4l: The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2

The binding sites of Calcium atom in the The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2 (pdb code 8e4l). This binding sites where shown within 5.0 Angstroms radius around Calcium atom.
In total 4 binding sites of Calcium where determined in the The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2, PDB code: 8e4l:
Jump to Calcium binding site number: 1; 2; 3; 4;

Calcium binding site 1 out of 4 in the The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 1 of The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Ca1201 b:132.7 occ:1.00 OE2 A:GLU782 2.5 137.5 1.0 OE1 A:GLN785 2.5 140.0 1.0 OD1 A:ASN799 2.6 133.8 1.0 OD2 A:ASP802 3.1 130.2 1.0 CD A:GLU782 3.3 137.5 1.0 HH12 A:ARG842 3.4 120.0 1.0 CG A:ASN799 3.4 133.8 1.0 HA A:ASN799 3.4 133.8 1.0 OE1 A:GLU782 3.4 137.5 1.0 HE21 A:GLN785 3.5 140.0 1.0 CD A:GLN785 3.5 140.0 1.0 NE2 A:GLN785 3.9 140.0 1.0 HD21 A:ASN799 4.0 133.8 1.0 ND2 A:ASN799 4.0 133.8 1.0 CA A:ASN799 4.2 133.8 1.0 NH1 A:ARG842 4.2 120.0 1.0 CG A:ASP802 4.3 130.2 1.0 CB A:ASN799 4.3 133.8 1.0 HH22 A:ARG842 4.4 120.0 1.0 N A:ASN799 4.4 133.8 1.0 HB2 A:ASP802 4.6 130.2 1.0 HH11 A:ARG842 4.6 120.0 1.0 HB3 A:ASN799 4.6 133.8 1.0 HE1 A:TYR793 4.6 143.8 1.0 H A:ASN799 4.7 133.8 1.0 HB3 A:GLN785 4.7 140.0 1.0 HB2 A:TRP798 4.7 122.0 1.0 HE22 A:GLN785 4.7 140.0 1.0 HD22 A:ASN799 4.8 133.8 1.0 CG A:GLU782 4.8 137.5 1.0 C A:TRP798 4.8 122.0 1.0 CG A:GLN785 4.9 140.0 1.0 HB2 A:GLN785 4.9 140.0 1.0 O A:TRP798 4.9 122.0 1.0 HB3 A:TRP798 4.9 122.0 1.0 HG2 A:GLU782 4.9 137.5 1.0 CB A:ASP802 4.9 130.2 1.0

Calcium binding site 2 out of 4 in the The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 2 of The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ B:Ca1201 b:132.7 occ:1.00 OE2 B:GLU782 2.5 137.5 1.0 OE1 B:GLN785 2.5 140.0 1.0 OD1 B:ASN799 2.6 133.8 1.0 OD2 B:ASP802 3.1 130.2 1.0 CD B:GLU782 3.3 137.5 1.0 HH12 B:ARG842 3.4 120.0 1.0 CG B:ASN799 3.4 133.8 1.0 HA B:ASN799 3.4 133.8 1.0 OE1 B:GLU782 3.4 137.5 1.0 HE21 B:GLN785 3.5 140.0 1.0 CD B:GLN785 3.5 140.0 1.0 NE2 B:GLN785 3.9 140.0 1.0 HD21 B:ASN799 4.0 133.8 1.0 ND2 B:ASN799 4.0 133.8 1.0 CA B:ASN799 4.2 133.8 1.0 NH1 B:ARG842 4.2 120.0 1.0 CG B:ASP802 4.3 130.2 1.0 CB B:ASN799 4.3 133.8 1.0 HH22 B:ARG842 4.4 120.0 1.0 N B:ASN799 4.4 133.8 1.0 HB2 B:ASP802 4.6 130.2 1.0 HH11 B:ARG842 4.6 120.0 1.0 HB3 B:ASN799 4.6 133.8 1.0 HE1 B:TYR793 4.6 143.8 1.0 H B:ASN799 4.7 133.8 1.0 HB3 B:GLN785 4.7 140.0 1.0 HB2 B:TRP798 4.7 122.0 1.0 HE22 B:GLN785 4.7 140.0 1.0 HD22 B:ASN799 4.8 133.8 1.0 CG B:GLU782 4.8 137.5 1.0 C B:TRP798 4.8 122.0 1.0 CG B:GLN785 4.9 140.0 1.0 HB2 B:GLN785 4.9 140.0 1.0 O B:TRP798 4.9 122.0 1.0 HB3 B:TRP798 4.9 122.0 1.0 HG2 B:GLU782 4.9 137.5 1.0 CB B:ASP802 4.9 130.2 1.0

Calcium binding site 3 out of 4 in the The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 3 of The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ca1201 b:132.7 occ:1.00 OE2 C:GLU782 2.5 137.5 1.0 OE1 C:GLN785 2.5 140.0 1.0 OD1 C:ASN799 2.6 133.8 1.0 OD2 C:ASP802 3.1 130.2 1.0 CD C:GLU782 3.3 137.5 1.0 HH12 C:ARG842 3.4 120.0 1.0 CG C:ASN799 3.4 133.8 1.0 HA C:ASN799 3.4 133.8 1.0 OE1 C:GLU782 3.4 137.5 1.0 HE21 C:GLN785 3.5 140.0 1.0 CD C:GLN785 3.5 140.0 1.0 NE2 C:GLN785 3.9 140.0 1.0 HD21 C:ASN799 4.0 133.8 1.0 ND2 C:ASN799 4.0 133.8 1.0 CA C:ASN799 4.2 133.8 1.0 NH1 C:ARG842 4.2 120.0 1.0 CG C:ASP802 4.3 130.2 1.0 CB C:ASN799 4.3 133.8 1.0 HH22 C:ARG842 4.4 120.0 1.0 N C:ASN799 4.4 133.8 1.0 HB2 C:ASP802 4.6 130.2 1.0 HH11 C:ARG842 4.6 120.0 1.0 HB3 C:ASN799 4.6 133.8 1.0 HE1 C:TYR793 4.6 143.8 1.0 H C:ASN799 4.7 133.8 1.0 HB3 C:GLN785 4.7 140.0 1.0 HB2 C:TRP798 4.7 122.0 1.0 HE22 C:GLN785 4.7 140.0 1.0 HD22 C:ASN799 4.8 133.8 1.0 CG C:GLU782 4.8 137.5 1.0 C C:TRP798 4.8 122.0 1.0 CG C:GLN785 4.9 140.0 1.0 HB2 C:GLN785 4.9 140.0 1.0 O C:TRP798 4.9 122.0 1.0 HB3 C:TRP798 4.9 122.0 1.0 HG2 C:GLU782 4.9 137.5 1.0 CB C:ASP802 4.9 130.2 1.0

Calcium binding site 4 out of 4 in the The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2


Mono view


Stereo pair view

A full contact list of Calcium with other atoms in the Ca binding site number 4 of The Open State Mouse TRPM8 Structure in Complex with the Cooling Agonist C3, Aitc, and Pi(4,5)P2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ca1201 b:132.7 occ:1.00 OE2 D:GLU782 2.5 137.5 1.0 OE1 D:GLN785 2.5 140.0 1.0 OD1 D:ASN799 2.6 133.8 1.0 OD2 D:ASP802 3.1 130.2 1.0 CD D:GLU782 3.3 137.5 1.0 HH12 D:ARG842 3.4 120.0 1.0 CG D:ASN799 3.4 133.8 1.0 HA D:ASN799 3.4 133.8 1.0 OE1 D:GLU782 3.4 137.5 1.0 HE21 D:GLN785 3.5 140.0 1.0 CD D:GLN785 3.5 140.0 1.0 NE2 D:GLN785 3.9 140.0 1.0 HD21 D:ASN799 4.0 133.8 1.0 ND2 D:ASN799 4.0 133.8 1.0 CA D:ASN799 4.2 133.8 1.0 NH1 D:ARG842 4.2 120.0 1.0 CG D:ASP802 4.3 130.2 1.0 CB D:ASN799 4.3 133.8 1.0 HH22 D:ARG842 4.4 120.0 1.0 N D:ASN799 4.4 133.8 1.0 HB2 D:ASP802 4.6 130.2 1.0 HH11 D:ARG842 4.6 120.0 1.0 HB3 D:ASN799 4.6 133.8 1.0 HE1 D:TYR793 4.6 143.8 1.0 H D:ASN799 4.7 133.8 1.0 HB3 D:GLN785 4.7 140.0 1.0 HB2 D:TRP798 4.7 122.0 1.0 HE22 D:GLN785 4.7 140.0 1.0 HD22 D:ASN799 4.8 133.8 1.0 CG D:GLU782 4.8 137.5 1.0 C D:TRP798 4.8 122.0 1.0 CG D:GLN785 4.9 140.0 1.0 HB2 D:GLN785 4.9 140.0 1.0 O D:TRP798 4.9 122.0 1.0 HB3 D:TRP798 4.9 122.0 1.0 HG2 D:GLU782 4.9 137.5 1.0 CB D:ASP802 4.9 130.2 1.0

Y.Yin, F.Zhang, S.Feng, K.J.Butay, M.J.Borgnia, W.Im, S.Y.Lee. Activation Mechanism of the Mouse Cold-Sensing TRPM8 Channel By Cooling Agonist and Pip 2. Science V. 378 D1268 2022.
ISSN: ESSN 1095-9203
PubMed: 36227998
DOI: 10.1126/SCIENCE.ADD1268